Kerek Ádám, Szabó Ábel, Jerzsele Ákos
Department of Pharmacology and Toxicology, University of Veterinary Medicine, István utca 2, 1078 Budapest, Hungary.
National Laboratory of Infectious Animal Diseases, Antimicrobial Resistance, Veterinary Public Health and Food Chain Safety, University of Veterinary Medicine, István utca 2, 1078 Budapest, Hungary.
Antibiotics (Basel). 2025 May 8;14(5):478. doi: 10.3390/antibiotics14050478.
and remain clinically significant pathogens in the waterfowl industry, causing substantial economic losses and posing potential zoonotic risks. Antimicrobial resistance (AMR) continues to spread in the poultry sector, making regular surveillance of bacterial isolates essential. : In this study, eight and eighteen strains were isolated from clinical cases in Hungarian waterfowl between 2022 and 2023. Minimum inhibitory concentration (MIC) values were determined for antibiotics of veterinary and public health significance. : For , high resistance rates were observed for spectinomycin, lincomycin, and tiamulin, while beta-lactam antibiotics (amoxicillin, ceftriaxone, and imipenem) demonstrated strong efficacy. Among the isolates, resistance to amoxicillin (89%) and enrofloxacin (61%) was notable, whereas ceftriaxone and doxycycline exhibited moderate antibacterial effects. : Our findings underscore the importance of targeted antimicrobial use in the waterfowl industry. Beta-lactam antibiotics remain effective, whereas rising resistance to fluoroquinolones and aminoglycosides raise serious concerns. Routine AMR surveillance and the adoption of alternative strategies are crucial for controlling infections and maintaining flock health.
并且仍然是水禽行业中具有临床意义的重要病原体，造成重大经济损失并带来潜在的人畜共患病风险。抗菌药物耐药性（AMR）在禽类部门持续传播，因此对细菌分离株进行定期监测至关重要。：在本研究中，2022年至2023年间从匈牙利水禽的临床病例中分离出8株和18株菌株。测定了具有兽医和公共卫生意义的抗生素的最低抑菌浓度（MIC）值。：对于，壮观霉素、林可霉素和泰妙菌素的耐药率较高，而β-内酰胺类抗生素（阿莫西林、头孢曲松和亚胺培南）显示出强大的疗效。在分离株中，对阿莫西林（89%）和恩诺沙星（61%）的耐药性值得注意，而头孢曲松和多西环素表现出中等抗菌效果。：我们的研究结果强调了在水禽行业中针对性使用抗菌药物的重要性。β-内酰胺类抗生素仍然有效，而对氟喹诺酮类和氨基糖苷类药物耐药性的上升引发了严重担忧。常规的AMR监测和采用替代策略对于控制感染和维持禽群健康至关重要。
