BACKGROUND/OBJECTIVES: Precision medicine is not just hype. Instead, it represents a high bar for developing more effective, safer, and better-tolerated therapies in medicine, without exception in psychiatry, including bipolar disorder (BD). A burgeoning body of narrative reviews and perspective papers has already appraised the boundaries of precision medicine in BD.

METHODS

This brief perspective follows a narrative, critical approach focusing explicitly on the antipsychotic management of BD using precision approaches.

RESULTS

While most controversies align with those previously appraised in BD's overall precision medicine approach, specific insights are provided herein.

CONCLUSIONS

Beyond other implications and the strengthened call for valid diagnostic coding systems, the implementation of shared decision-making tools and pharmacogenomics studies focusing on persons with BD are particularly warranted.