Li Guanghui, Wei Daren, Lyu Ze, Xing Yalong, Li Yan, Song Wu
Faculty of Innovation and Design, City University of Macau, Macau 999078, China.
College of Mechanical Engineering and Automation, Huaqiao University, Xiamen 361021, China.
Brain Sci. 2025 Apr 24;15(5):438. doi: 10.3390/brainsci15050438.
Art-based interventions have been shown to enhance communication skills in children with autism spectrum disorder (ASD), yet their impact on prefrontal hemodynamics remains unclear. This study employed functional near-infrared spectroscopy (fNIRS) to examine hemoglobin oxygenation (HbO) changes in the prefrontal cortex of school-age children with ASD, providing empirical support for its therapeutic efficacy. Sixty age-matched children participated in a 9-week art therapy program, including twenty ASD children and forty typically developing peers. Assessments included self-portrait drawing (SPD), the Diagnostic Drawing Series (DDS), and the General Quality of Life Inventory (GQOL-74). In addition, we performed fNIRS measurements in the ASD participants and observed changes in prefrontal HbO at rest and while drawing. The drawing intervention significantly enhanced drawing ability, emotional expression, and cognitive skills, with the intervention group outperforming the controls. ASD participants exhibited distinct prefrontal connectivity patterns with visual, motor, and language-related regions, including the dorsolateral prefrontal cortex, frontal eye field, and Broca's area. Task-based painting interventions indirectly influenced the frontal lobe's hemodynamic characteristics, indicating drawing intervention as an effective intervention for ASD.
基于艺术的干预已被证明能提高自闭症谱系障碍（ASD）儿童的沟通能力，但其对前额叶血流动力学的影响仍不清楚。本研究采用功能近红外光谱技术（fNIRS）来检测ASD学龄儿童前额叶皮层的血红蛋白氧合（HbO）变化，为其治疗效果提供实证支持。60名年龄匹配的儿童参加了为期9周的艺术治疗项目，其中包括20名ASD儿童和40名发育正常的同龄人。评估包括自画像绘制（SPD）、诊断绘图系列（DDS）和生活质量综合量表（GQOL-74）。此外，我们对ASD参与者进行了fNIRS测量，并观察了他们在休息和绘画时前额叶HbO的变化。绘画干预显著提高了绘画能力、情感表达和认知技能，干预组的表现优于对照组。ASD参与者在前额叶与视觉、运动和语言相关区域（包括背外侧前额叶皮层、额叶眼区和布罗卡区）呈现出独特的连接模式。基于任务的绘画干预间接影响了额叶的血流动力学特征，表明绘画干预是一种对ASD有效的干预方法。
