Ibancovichi-Camarillo José Antonio, Chávez-Monteagudo Julio Raúl, De Paz-Campos Marco Antonio, Gutiérrez-Olvera Lilia, Sumano-López Héctor Salvador
Anestesiología y Analgesia, Facultad de Medicina Veterinaria, Universidad Autónoma del Estado de México, UAEMex, Toluca 50000, Mexico.
Departamento de Ciencias Pecuarias, Facultad de Estudios Superiores Cuautitlán, Hospital de Pequeñas Especies, Universidad Nacional Autónoma de México, UNAM, Cuautitlán Izcalli 54740, Mexico.
Animals (Basel). 2025 May 10;15(10):1381. doi: 10.3390/ani15101381.
To evaluate the effect of oral administration of 10 mg kg tapentadol on dogs' minimum alveolar concentration of isoflurane. The MAC of isoflurane was determined in seven dogs without previous medication (Group MAC) and 2 h 30 min after the administration of 10 mg kg of tapentadol orally (Group MAC). The MAC was determined by pinching the fourth finger of the pelvic limb. Data normality was analyzed using the Shapiro-Wilk test. Student's t-test was used to evaluate the effect of tapentadol on isoflurane MAC and cardiovascular variables. The minimum alveolar concentration obtained in the Group MAC was 1.52 ± 0.02%, and in the Group MAC, it was 1.47 ± 0.03%, observing a significant statistical difference between groups ( = 0.01). The reduction in the MAC caused by administering 10 mg kg of Tapentadol was 3.29%. No statistically significant differences were observed when the heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure were compared between groups. The oral administration of 10 mg kg tapentadol reduces dogs' minimum alveolar concentration of isoflurane without alterations in the heart rate and systemic blood pressure.
为评估口服10毫克/千克曲马多对犬异氟烷最低肺泡浓度的影响。在7只未预先用药的犬（MAC组）以及口服10毫克/千克曲马多2小时30分钟后（MAC组）测定异氟烷的最低肺泡浓度。通过捏压后肢第四指来确定最低肺泡浓度。使用夏皮罗-威尔克检验分析数据正态性。采用学生t检验评估曲马多对异氟烷最低肺泡浓度和心血管变量的影响。MAC组获得的最低肺泡浓度为1.52±0.02%，MAC组为1.47±0.03%，两组间观察到显著统计学差异（P = 0.01）。给予10毫克/千克曲马多导致最低肺泡浓度降低3.29%。比较两组间心率、收缩压、舒张压和平均动脉压时未观察到统计学显著差异。口服10毫克/千克曲马多可降低犬异氟烷的最低肺泡浓度，且不改变心率和全身血压。
