Hoffman Elizabeth A, Aarnes Turi K, Ricco Pereira Carolina H, Lerche Phillip, Bednarski Richard M, McLoughlin Mary A
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.
Vet Anaesth Analg. 2018 Nov;45(6):754-759. doi: 10.1016/j.vaa.2018.08.002. Epub 2018 Sep 5.
To determine the effect of oral trazodone on the minimum alveolar concentration (MAC) of isoflurane in dogs.
Prospective blinded, single-observer, randomized crossover experimental study.
Six adult (age 6.8 ± 1.6 months) healthy dogs (three males and three females), weighing 24.8 ± 3.4 kg (mean ± standard deviation).
Each dog was anesthetized twice with a minimum of 7 days between anesthetic episodes. Dogs were randomly assigned to be administered two treatments in a crossover design: premedication with trazodone (8 mg kg; TRAZ-ISO) orally 2 hours prior to an anesthetic episode or no (ISO). Dogs were anesthetized with intravenous propofol (6 mg kg) and isoflurane in >95% oxygen. Isoflurane MAC was determined using an iterative bracketing technique with electrodes placed in the buccal mucosa. Hemodynamic variables were compared at the lowest end-tidal isoflurane concentration at which each dog did not respond. A paired t test was used to assess the effect of treatment on outcome variables with significance set to a value of p < 0.05.
The MAC concentration (mean ± standard deviation) in dogs administered TRAZ-ISO was 0.85 ± 0.17% compared with 1.02 ± 0.11% in those administered ISO (p = 0.01, 95% confidence interval -0.25 to -0.05), resulting in a mean MAC reduction of 17 ± 12%. There were no differences in hemodynamic variables between treatments.
Premedication of dogs with oral trazodone (8 mg kg) 2 hours prior to anesthetic induction has a significant isoflurane MAC sparing effect with no significant observed hemodynamic benefit.
确定口服曲唑酮对犬异氟烷最低肺泡浓度（MAC）的影响。
前瞻性盲法、单观察者、随机交叉实验研究。
6只成年（年龄6.8±1.6个月）健康犬（3只雄性和3只雌性），体重24.8±3.4千克（均值±标准差）。
每只犬接受两次麻醉，麻醉期间至少间隔7天。犬采用交叉设计随机分配接受两种处理：在麻醉前2小时口服曲唑酮（8毫克/千克；TRAZ-ISO）进行预处理或不进行预处理（ISO）。犬通过静脉注射丙泊酚（6毫克/千克）和在>95%氧气中吸入异氟烷进行麻醉。使用迭代括值技术并将电极置于颊黏膜来测定异氟烷MAC。在每只犬无反应的最低呼气末异氟烷浓度下比较血流动力学变量。采用配对t检验评估处理对结果变量的影响，显著性设定为p<0.05。
接受TRAZ-ISO处理的犬的MAC浓度（均值±标准差）为0.85±0.17%，而接受ISO处理的犬为1.02±0.11%（p = 0.01，95%置信区间为-0.25至-0.05），导致MAC平均降低17±12%。处理之间的血流动力学变量无差异。
麻醉诱导前2小时给犬口服曲唑酮（8毫克/千克）进行预处理具有显著的异氟烷MAC节省效应，但未观察到显著的血流动力学益处。
