Timurtas Eren, Sharkh Ahmed-Abou, Mate Kedar K V, Dawes Helen, Mayo Nancy E
Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Marmara University, Istanbul 34722, Turkey.
School of Physical and Occupational Therapy, Faculty of Medicine, McGill University, Montreal, QC H3G 1Y5, Canada.
Bioengineering (Basel). 2025 May 21;12(5):551. doi: 10.3390/bioengineering12050551.
Parkinson's disease (PD) affects both motor and non-motor functions, but their interactions are understudied. This study aims to explore the relationships between non-motor and motor effects of PD, focusing on depression, fatigue, gait parameters, concentration, and physical function.
This is a secondary analysis of baseline data from a randomized feasibility study using a commercially available Heel2Toe™ sensor, providing auditory feedback for gait quality. The sample included PD patients with gait impairments who walked without aids. Non-motor measures were depression, fatigue, and concentration, while motor measures included gait quality (angular velocity and variability during heel strike, push-off, foot swing) and physical function (6MWT, Mini-BESTest, Neuro-QoL). Path analysis was used to assess direct and indirect effects.
Among 27 participants, fatigue impacted heel strike, which affected Neuro-QoL. Mood influenced push-off and Neuro-QoL, with a direct link to 6MWT. Foot swing affected Mini-BESTest and Neuro-QoL directly.
Non-motor PD effects directly influenced specific gait parameters and physical function indicators, highlighting potential digital biomarkers of fatigue and mood for targeted interventions.
帕金森病（PD）会影响运动和非运动功能，但其相互作用尚未得到充分研究。本研究旨在探讨PD非运动和运动效应之间的关系，重点关注抑郁、疲劳、步态参数、注意力和身体功能。
这是一项对随机可行性研究基线数据的二次分析，该研究使用市售的Heel2Toe™传感器，为步态质量提供听觉反馈。样本包括无辅助行走的步态受损的PD患者。非运动测量指标为抑郁、疲劳和注意力，而运动测量指标包括步态质量（足跟触地、蹬离、足摆动期间的角速度和变异性）和身体功能（6分钟步行试验、Mini-BESTest、神经生活质量量表）。采用路径分析评估直接和间接效应。
在27名参与者中，疲劳影响足跟触地，进而影响神经生活质量量表。情绪影响蹬离和神经生活质量量表，并与6分钟步行试验有直接关联。足摆动直接影响Mini-BESTest和神经生活质量量表。
PD的非运动效应直接影响特定的步态参数和身体功能指标，突出了疲劳和情绪作为潜在数字生物标志物用于靶向干预的可能性。
