Čolak Emina, Žorić Lepša
Institute of Medical Biochemistry, University Clinical Centre of Serbia, 11000 Belgrade, Serbia.
Clinic for Eye Diseases, University Clinical Centre of Serbia, 11000 Belgrade, Serbia.
Genes (Basel). 2025 Apr 25;16(5):489. doi: 10.3390/genes16050489.
Obesity is a medical condition influenced by many factors and manifested by the excessive accumulation of fat. It is well documented that oxidative stress plays a significant role in the development of obesity and its related diseases. The antioxidant system's enzymes, such as catalase, superoxide dismutase, glutathione peroxidase, paroxonase, etc., play a significant role in maintaining the oxidant-antioxidant balance in living organisms. Genetic variants of antioxidant system genes may affect the antioxidant system and its efficacy, which can lead to increased oxidative stress and higher risk for the development of obesity and its comorbidities. This review is focused on genetic variants such as single nucleotide polymorphisms of some antioxidant enzymes, ROS generators and transcription factors, and their impact on increased oxidative stress and the development of obesity and medical conditions related to obesity, like insulin resistance and metabolic syndrome.
肥胖是一种受多种因素影响的医学状况，表现为脂肪过度堆积。大量文献记载，氧化应激在肥胖及其相关疾病的发展中起重要作用。抗氧化系统的酶，如过氧化氢酶、超氧化物歧化酶、谷胱甘肽过氧化物酶、对氧磷酶等，在维持生物体氧化还原平衡中起重要作用。抗氧化系统基因的遗传变异可能影响抗氧化系统及其功效，进而导致氧化应激增加以及肥胖及其合并症发生风险升高。本综述聚焦于某些抗氧化酶、活性氧生成器和转录因子的单核苷酸多态性等遗传变异，以及它们对氧化应激增加、肥胖及其相关病症（如胰岛素抵抗和代谢综合征）发展的影响。
