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肥胖及其相关代谢合并症中的转录因子和表观遗传机制。

Transcriptional Factors and Epigenetic Mechanisms in Obesity and Related Metabolic Comorbidities.

机构信息

Institut Jean-Lamour, The University of Lorraine, UMR 7198 CNRS, CEDEX, 54505 Vandoeuvre les Nancy, France.

出版信息

Cells. 2022 Aug 14;11(16):2520. doi: 10.3390/cells11162520.

DOI:10.3390/cells11162520
PMID:36010597
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9406382/
Abstract

Recent advances in the study of chromatin remodeling and transcriptional machinery complex dysfunction, and how they drive metabolic-related gene expression have considerably increased our understanding of several molecular processes underlaying obesity and its complications [...].

摘要

近年来，染色质重塑和转录机制复合物功能障碍的研究进展，以及它们如何驱动与代谢相关的基因表达，极大地增加了我们对肥胖及其并发症所涉及的几个分子过程的理解[...]。

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Extract and Individual Synthesized Component Derivatives Induce Activating-Transcription-Factor-3-Mediated Anti-Obesity Effects and Attenuate Obesity-Induced Metabolic Disorder by Suppressing C/EBPα in High-Fat-Induced Obese Mice.提取和个体化合成成分衍生物通过抑制高脂诱导肥胖小鼠中 C/EBPα 诱导激活转录因子 3 介导的抗肥胖作用并减轻肥胖引起的代谢紊乱。
Cells. 2022 Mar 17;11(6):1022. doi: 10.3390/cells11061022.
3
Epigenetic Dysregulation of the () Gene Associates with Subcutaneous Adipocyte Hypertrophy in Human Obesity.（）基因的表观遗传失调与人类肥胖症的皮下脂肪细胞肥大有关。
Cells. 2022 Feb 18;11(4):728. doi: 10.3390/cells11040728.
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MXD3 Promotes Obesity and the Androgen Receptor Signaling Pathway in Gender-Disparity Hepatocarcinogenesis.MXD3 促进性别差异肝癌发生中的肥胖和雄激素受体信号通路。
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