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水果提取物对丙戊酸钠诱导的BALB/c小鼠产后自闭症的提取、植物化学特征及神经保护活性

Extraction, Phytochemical profile, and neuroprotective activity of fruit extract against sodium valproate-induced postnatal autism in BALB/c mice.

作者信息

Gouda Balaji, Sinha Sukesh Narayan, Sangaraju Rajendra, Huynh Tien, Patangay Shashikala, Venkata Mullapudi Surekha, Mungamuri Sathish Kumar, Patil Pradeep B, Periketi Madhusudhana Chary

机构信息

Division of Food Safety, Indian Council of Medical Research-National Institute of Nutrition, Jamai-Osmania, Tarnaka, Hyderabad, Telangana- 500007, India.

Department of Pharmacy, University College of Technology, Osmania University, Hyderabad-500027, India.

出版信息

Heliyon. 2024 Jul 20;10(15):e34992. doi: 10.1016/j.heliyon.2024.e34992. eCollection 2024 Aug 15.

DOI:10.1016/j.heliyon.2024.e34992
PMID:39157403
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11327600/
Abstract

The aim of the present study was to evaluate the effect of the ethyl acetate fraction of amla (EAFA) extract on valproic acid (VPA)-induced postnatal autism in BALB/c mice. Our study revealed that mice treated with VPA on postnatal day 14 (PND14) showed significant abnormal behaviours such as social interaction, social affiliation, anxiety, and motor coordination compared to the control group, while EAFA extract treatment (100 mg/kg) ameliorated these symptoms. Our study highlights the protective effect of EAFA extract on improving behavioural alterations, significantly restoring anti-oxidative enzymes such as GST and GR, and reducing MDA and NO levels. Furthermore, the EAFA-treated group significantly lowered the proinflammatory markers (IL-1β and TNF-α) and the expression of up-regulated 5-HT1D, 5-HT2A, and D2 receptor proteins. Based on histopathological studies, the percentage of neuronal injury in the EAFA-treated group as well as cellular structural changes were reduced using SEM analysis. In conclusion, the present study suggests that treatment with EAFA extract ameliorates VPA-induced autism due to its anti-oxidant and neuroprotective activity.

摘要

本研究的目的是评估余甘子乙酸乙酯提取物（EAFA）对丙戊酸（VPA）诱导的BALB/c小鼠产后自闭症的影响。我们的研究表明，与对照组相比，在出生后第14天（PND14）用VPA处理的小鼠表现出显著的异常行为，如社交互动、社交依恋、焦虑和运动协调，而EAFA提取物处理（100mg/kg）改善了这些症状。我们的研究强调了EAFA提取物对改善行为改变、显著恢复抗氧化酶如谷胱甘肽S-转移酶（GST）和谷胱甘肽还原酶（GR）以及降低丙二醛（MDA）和一氧化氮（NO）水平的保护作用。此外，EAFA处理组显著降低了促炎标志物（白细胞介素-1β和肿瘤坏死因子-α）以及上调的5-羟色胺1D（5-HT1D）、5-羟色胺2A（5-HT2A）和多巴胺D2受体蛋白的表达。基于组织病理学研究，使用扫描电子显微镜（SEM）分析，EAFA处理组的神经元损伤百分比以及细胞结构变化均有所减少。总之，本研究表明，EAFA提取物治疗可改善VPA诱导的自闭症，这归因于其抗氧化和神经保护活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/002e/11327600/a03ed6b79a20/gr11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/002e/11327600/f7c9f2fe39b4/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/002e/11327600/6bf23d091ff3/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/002e/11327600/064ce2aea1d2/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/002e/11327600/d27b5d311ac4/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/002e/11327600/12bdf7e2455f/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/002e/11327600/0b2d5d6116d5/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/002e/11327600/2890e349914f/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/002e/11327600/f4470ec00ab0/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/002e/11327600/b24bb01714f5/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/002e/11327600/9315a8b1ef6c/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/002e/11327600/a03ed6b79a20/gr11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/002e/11327600/f7c9f2fe39b4/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/002e/11327600/6bf23d091ff3/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/002e/11327600/064ce2aea1d2/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/002e/11327600/d27b5d311ac4/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/002e/11327600/12bdf7e2455f/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/002e/11327600/0b2d5d6116d5/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/002e/11327600/2890e349914f/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/002e/11327600/f4470ec00ab0/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/002e/11327600/b24bb01714f5/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/002e/11327600/9315a8b1ef6c/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/002e/11327600/a03ed6b79a20/gr11.jpg

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