Torraco Astrid, Di Nicolantonio Sara, Cardisciani Martina, Ortu Eleonora, Pietropaoli Davide, Altamura Serena, Del Pinto Rita
Department of Clinical Medicine, Public Health, Life and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
Department of Physical and Chemical Science, University of L'Aquila, 67100 L'Aquila, Italy.
Medicina (Kaunas). 2025 May 14;61(5):888. doi: 10.3390/medicina61050888.
: Dysbiosis of the oral-gut axis is related to several extraintestinal inflammatory diseases, including endometriosis. This study aims to assess the microbial landscape and pathogenic potential of distinct biological niches during endometriosis. : A microbiome meta-analysis was conducted on 182 metagenomic sequences (79 of fecal and 103 of vaginal origin) from women with and without endometriosis. Fecal and vaginal microbial diversity, differential abundance, and functional analysis based on disease status were assessed. Random forest, gradient boosting, and generalized linear modeling were used to predict endometriosis based on differentially enriched bacteria. : Only intestinal microbes displayed distinctive taxonomic and functional characteristics in women with endometriosis compared to control women. Taxonomic differences were quantified using the microbial endometriosis index (MEI), which effectively distinguished between individuals with and without the disease. The observed functional enrichment pointed to proinflammatory pathways previously related to endometriosis development. : Dysbiosis in the oral-gut microbial community appears to play a prevalent role in endometriosis. Our findings pave the ground for future studies exploring the potential mechanistic involvement of the oral-gut axis in disease pathogenesis.
口腔-肠道轴的生态失调与包括子宫内膜异位症在内的几种肠外炎症性疾病有关。本研究旨在评估子宫内膜异位症期间不同生物龛的微生物格局和致病潜力。：对来自患有和未患有子宫内膜异位症的女性的182个宏基因组序列（79个粪便样本和103个阴道样本）进行了微生物组荟萃分析。评估了基于疾病状态的粪便和阴道微生物多样性、差异丰度和功能分析。使用随机森林、梯度提升和广义线性模型基于差异富集的细菌预测子宫内膜异位症。：与对照女性相比，只有患有子宫内膜异位症的女性肠道微生物表现出独特的分类学和功能特征。使用微生物子宫内膜异位症指数（MEI）对分类学差异进行量化，该指数能有效区分患病个体和未患病个体。观察到的功能富集指向先前与子宫内膜异位症发展相关的促炎途径。：口腔-肠道微生物群落的生态失调似乎在子宫内膜异位症中起普遍作用。我们的研究结果为未来探索口腔-肠道轴在疾病发病机制中的潜在机制参与的研究奠定了基础。
