探索mRNA甲基化在昆虫生物学及抗性中的作用。

Exploring the Role of mRNA Methylation in Insect Biology and Resistance.

作者信息

Zhang Jiayang, Lin Luobin, Huang Botian, Liu Huoxi, Li Huaqin, Wu Wenmei

机构信息

Guangdong Provincial Key Laboratory of Advanced Drug Delivery, Guangdong Provincial Engineering Centerof Topical Precise Drug Delivery System, School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China.

School of Health Sciences, Guangzhou Xinhua University, Guangzhou 510520, China.

出版信息

Insects. 2025 Apr 28;16(5):463. doi: 10.3390/insects16050463.

DOI:10.3390/insects16050463

PMID:40429176

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12111879/

Abstract

RNA methylation, characterized by modifications such as -methyladenosine, 5-methylcytosine, and -methyladenosine plays a crucial role in post-transcriptional gene regulation across diverse biological systems. While research on RNA methylation has predominantly focused on mammals, particularly its roles in epigenetic regulation and cancer biology, recent studies in insects have begun to explore their extensive functions in insect physiology. This review examines the mechanisms by which RNA methylation regulates growth, development, reproduction, environmental adaptation, and immune response in insects, providing insights into the biological characteristics of these organisms without prematurely speculating on pest control strategies. It aims to offer valuable insights into the role of RNA methylation in insect biology and resistance.

摘要

RNA甲基化以N6-甲基腺苷、5-甲基胞嘧啶和N1-甲基腺苷等修饰为特征，在各种生物系统的转录后基因调控中起着至关重要的作用。虽然对RNA甲基化的研究主要集中在哺乳动物上，特别是其在表观遗传调控和癌症生物学中的作用，但最近对昆虫的研究已经开始探索其在昆虫生理学中的广泛功能。这篇综述研究了RNA甲基化调节昆虫生长、发育、繁殖、环境适应和免疫反应的机制，在不过早推测害虫控制策略的情况下，深入了解这些生物的生物学特性。其目的是为RNA甲基化在昆虫生物学和抗性中的作用提供有价值的见解。