Current and Future Spatial Distribution of the in Peru Based on Topoclimatic Analysis and Climate Change Scenarios.

Dengue, a febrile disease that has caused epidemics and deaths in South America, especially Peru, is vectored by the mosquito. Despite the seriousness of dengue fever, and the expanding range of , future distributions of the vector and disease in the context of climate change have not yet been clearly determined. Expanding on previous findings, our study employed bioclimatic and topographic variables to model both the present and future distribution of the mosquito using the Maximum Entropy algorithm (MaxEnt). The results indicate that 10.23% (132,053.96 km) and 23.65% (305,253.82 km) of Peru's surface area possess regions with high and moderate distribution probabilities, respectively, predominantly located in the departments of San Martín, Piura, Loreto, Lambayeque, Cajamarca, Amazonas, and Cusco. Moreover, based on projected future climate scenarios, it is anticipated that areas with a high probability of distribution will undergo expansion; specifically, the extent of these areas is estimated to increase by 4.47% and 2.99% by the years 2070 and 2100, respectively, under SSP2-4.5 in the HadGEM-GC31-LL model. Given the increasing dengue epidemic in Peru in recent years, our study seeks to identify tools for effectively addressing this pressing public health concern. Consequently, this research serves as a foundational framework for assessing areas with the highest likelihood of distribution in response to projected climate change in the second half of the 21st century.