Sodov Ulziizaya, Zuunnast Khishigsuren, Stefan Hermann, Avirmed Tovuudorj
Intermed Hospital, Ulaanbaatar 17040, Mongolia.
Department of Psychiatry, School of Medicine, Mongolian National University of Medical Sciences, Ulaanbaatar 13270, Mongolia.
J Clin Med. 2025 May 12;14(10):3372. doi: 10.3390/jcm14103372.
Epilepsy is a chronic neurological disorder, with cognitive impairment being one of its most significant comorbidities. While the majority of individuals with epilepsy maintain regular intellectual abilities, they are more likely to experience cognitive impairment compared to a healthy control group of the same age and educational level. This study aimed to assess cognitive impairment during epilepsy, particularly temporal lobe epilepsy, and to evaluate the effectiveness of using the Montreal Cognitive Assessment (MoCA) test for cognitive screening in individuals with epilepsy. One hundred and fifty subjects were included between 2022 and 2023, which were divided into 50 people diagnosed with temporal lobe epilepsy (TLE), 50 people with other types of epilepsy according to the International League Against Epilepsy (ILAE), and 50 healthy controls without epilepsy (HC). Significant differences were found in the total mean scores of the MoCA between TLE, other types of epilepsy, and healthy control groups ( = 0.000), particularly in visuospatial orientation, concentration, memory recall, abstraction, and language skills. Evaluating cognitive impairment in epilepsy involves comprehensive neuropsychological assessments, which have significantly advanced in recent years. Nevertheless, we consider the Montreal Cognitive Assessment (MoCA) test to be an appropriate initial screening tool for assessing cognitive impairment in epilepsy.
癫痫是一种慢性神经疾病，认知障碍是其最显著的合并症之一。虽然大多数癫痫患者保持正常的智力水平，但与年龄和教育程度相同的健康对照组相比，他们更有可能出现认知障碍。本研究旨在评估癫痫，特别是颞叶癫痫患者的认知障碍，并评估使用蒙特利尔认知评估量表（MoCA）对癫痫患者进行认知筛查的有效性。2022年至2023年纳入了150名受试者，分为50名被诊断为颞叶癫痫（TLE）的患者、50名根据国际抗癫痫联盟（ILAE）诊断为其他类型癫痫的患者以及50名无癫痫的健康对照者（HC）。在TLE组、其他类型癫痫组和健康对照组之间，MoCA的总平均分存在显著差异（ = 0.000），特别是在视觉空间定向、注意力、记忆回忆、抽象思维和语言技能方面。评估癫痫患者的认知障碍需要进行全面的神经心理学评估，近年来这方面有了显著进展。然而，我们认为蒙特利尔认知评估量表（MoCA）测试是评估癫痫患者认知障碍的一种合适的初步筛查工具。
