Weigl Markus Philipp, Feurstein Benedikt, Clemens Patrick, Attenberger Christian, Jäger Tarkan, Emmanuel Klaus, Königsrainer Ingmar, Tschann Peter
Department of General and Thoracic Surgery, Academic Teaching Hospital, 6800 Feldkirch, Austria.
Department of Radio-Oncology, Academic Teaching Hospital, 6800 Feldkirch, Austria.
J Clin Med. 2025 May 14;14(10):3438. doi: 10.3390/jcm14103438.
: Opinions concerning the role of obesity and changes in muscle mass in individuals with malignancies vary. It is believed that decreased fat tissue leads to a higher complication rate, while decreased muscle mass results in a poorer oncologic outcome. This study aimed to evaluate the impact of fat distribution and skeletal muscle mass on postoperative morbidity and long-term oncological outcomes in patients with non-metastatic colon cancer. : Between 2012 and 2018, a total of 129 patients with stage I-III colon cancer were evaluated. Abdominal CT scans were used to assess muscle mass and fat tissue (subcutaneous and visceral). Differences in postoperative morbidity and long-term oncologic outcome were analyzed and compared. : No significant differences occurred concerning complication rate or anastomotic leakage. Individuals with altered body composition parameters had a shorter length of hospital stay ( = 0.046) and an increased duration of surgery ( = 0.029). In patients with an ASA III score, altered fat tissue distribution was associated with improvements in both overall and disease-free survival ( = 0.031 and = 0.027, respectively) but also resulted in longer hospital stay. : Changes in body composition parameters lead to alterations in economic factors as well as changes in oncologic survival, especially in patients with higher ASA scores. No differences in morbidity were observed.
关于肥胖和肌肉量变化在恶性肿瘤患者中的作用，观点各异。人们认为脂肪组织减少会导致更高的并发症发生率，而肌肉量减少会导致更差的肿瘤学结局。本研究旨在评估脂肪分布和骨骼肌量对非转移性结肠癌患者术后发病率和长期肿瘤学结局的影响。：2012年至2018年期间，共评估了129例I - III期结肠癌患者。腹部CT扫描用于评估肌肉量和脂肪组织（皮下和内脏）。分析并比较术后发病率和长期肿瘤学结局的差异。：在并发症发生率或吻合口漏方面未出现显著差异。身体成分参数改变的个体住院时间较短（P = 0.046），手术时间延长（P = 0.029）。在ASA III级评分的患者中，脂肪组织分布改变与总生存期和无病生存期的改善相关（分别为P = 0.031和P = 0.027），但也导致住院时间延长。：身体成分参数的变化会导致经济因素的改变以及肿瘤学生存期的变化，尤其是在ASA评分较高的患者中。未观察到发病率的差异。
