Munteanu Roxana Mihaela, Voicu Bogdan, Șandru Diana, Solyom Arpad, Făgăraș Pia Simona, Pop Tudor Sorin
Doctoral School of Medicine and Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, 540142 Targu Mures, Romania.
OKF Medical Center Targu Mures, 540027 Targu Mures, Romania.
J Clin Med. 2025 May 21;14(10):3593. doi: 10.3390/jcm14103593.
: This retrospective study aimed to evaluate whether PRP infiltrations improve quadriceps muscle strength recovery following anterior cruciate ligament reconstruction (ACLR), while minimizing the recovery time required to resume daily activities and sports. Numerous studies have explored the use of platelet-rich plasma (PRP) in treating ACL injuries. PRP therapy has demonstrated high efficacy in accelerating ligament healing in animal models. However, clinical trials involving human participants have reported inconsistent results regarding the effects of PRP on ACL reconstruction outcomes. : Between 2020 and 2024, a total of 68 subjects who underwent ACLR were included in the study. Participants were divided into two groups, namely a treatment group that followed a standard rehabilitation protocol and received PRP infiltrations, and a control group that followed the same protocol without PRP treatment. Muscle strength was assessed using the isometric max strength balance (IMSB) test and the concentric max strength balance (CMSB) test, both performed using the Kineo Intelligent Load device (Globus Kineo 7000, Italian Excellence, Rome, Italy). : The results of IMSB test showed a significant difference between treatment groups according to a two-way ANOVA test (F(1, 198) = 7.345; = 0.0073). The PRP-treated group showed significantly higher quadriceps muscle strength at 6 months (34.9 ± 9.6 vs. 30.0 ± 8.2 kg). The CMSB test also showed a significant difference at 6 months (F(1, 198) = 5.976; = 0.00154), with the PRP-treated group having significantly higher concentric muscle strength (35.5 ± 9.5 vs. 30.7 ± 8.5 kg). : These findings suggest that post-ligamentoplasty PRP infiltrations may have beneficial effects on muscle strength recovery. However, further prospective studies with larger sample sizes are necessary to confirm these results.
本回顾性研究旨在评估富血小板血浆（PRP）注射是否能改善前交叉韧带重建（ACLR）后股四头肌力量的恢复，同时将恢复日常活动和运动所需的时间减至最短。许多研究探讨了富血小板血浆（PRP）在治疗前交叉韧带损伤中的应用。PRP疗法在动物模型中已证明在加速韧带愈合方面具有高效性。然而，涉及人类受试者的临床试验报告了关于PRP对ACLR结果影响的不一致结果。
在2020年至2024年期间，共有68名接受ACLR的受试者纳入本研究。参与者被分为两组，即遵循标准康复方案并接受PRP注射的治疗组，以及遵循相同方案但未接受PRP治疗的对照组。使用等长最大力量平衡（IMSB）测试和向心最大力量平衡（CMSB）测试评估肌肉力量，这两项测试均使用Kineo智能负荷设备（意大利罗马Globus Kineo 7000）进行。
IMSB测试结果显示，根据双向方差分析（F(1, 198) = 7.345；P = 0.0073），治疗组之间存在显著差异。接受PRP治疗的组在6个月时股四头肌力量显著更高（34.9±9.6 vs. 30.0±8.2千克）。CMSB测试在6个月时也显示出显著差异（F(1, 198) = 5.976；P = 0.00154），接受PRP治疗的组向心肌肉力量显著更高（35.5±9.5 vs. 30.7±8.5千克）。
这些发现表明，韧带成形术后PRP注射可能对肌肉力量恢复有有益影响。然而，需要进一步开展更大样本量的前瞻性研究来证实这些结果。
