Radbakhsh Shabnam, Najar Mehdi, Merimi Makram, Benderdour Mohamed, Fernandes Julio C, Martel-Pelletier Johanne, Pelletier Jean-Pierre, Fahmi Hassan
Osteoarthritis Research Unit, University of Montreal Hospital Research Center (CRCHUM), Montreal, QC H2X 0A9, Canada.
Int J Mol Sci. 2025 May 21;26(10):4955. doi: 10.3390/ijms26104955.
Osteoarthritis (OA) is a chronic joint disorder characterized by progressive degeneration of articular cartilage, pain, synovial inflammation, and bone remodeling. Post-transcriptional RNA modifications, known as epitranscriptome, are a group of biochemical alterations in the primary RNA transcript that might influence RNA structure, stability, and function. Different kinds of RNA modifications have been recognized, such as methylation, acetylation, pseudouridylation, and phosphorylation. N6-methyladenosine (m6A), 5-methylcytosine (m5C), N7-methylguanosine (m7G), 2'-O-ribose methylation (2'-O-Me), and pseudouridylation (Ψ) are the most prevalent RNA modifications. Recent studies have shown that disruption in these modifications can interfere with gene expression and protein function. Here, we will review all types of RNA modifications and how they contribute to the onset and progression of OA. To the best of our knowledge, this is the first review comprehensively addressing all epitranscriptomic modifications in OA.
骨关节炎（OA）是一种慢性关节疾病，其特征为关节软骨进行性退变、疼痛、滑膜炎症和骨重塑。转录后RNA修饰，即所谓的表观转录组，是初级RNA转录本中的一组生化改变，可能影响RNA的结构、稳定性和功能。已识别出不同类型的RNA修饰，如甲基化、乙酰化、假尿苷化和磷酸化。N6-甲基腺苷（m6A）、5-甲基胞嘧啶（m5C）、N7-甲基鸟苷（m7G）、2'-O-核糖甲基化（2'-O-Me）和假尿苷化（Ψ）是最普遍的RNA修饰。最近的研究表明，这些修饰的破坏会干扰基因表达和蛋白质功能。在此，我们将综述所有类型的RNA修饰及其如何促进OA的发生和发展。据我们所知，这是第一篇全面阐述OA中所有表观转录组修饰的综述。
