Munteanu Ioana, Burdușel Beatrice, Coca Catalin Constantin, Zisu Dănuț, Gheorghevici Constantin, Diaconu George Alexandru, Stan Diana Georgiana, Feraru Nicolae, Tivda Andrei, Popa Cristian George, Mihălțan Florin Dumitru, Marginean Corina
Faculty of Medicine, Titu Maiorescu University, 040441 Bucharest, Romania.
"Marius Nasta" Institute of Pneumophtisiology, 050159 Bucharest, Romania.
Life (Basel). 2025 May 12;15(5):773. doi: 10.3390/life15050773.
This article reports the case of a patient with a gastric neoplasm and total gastrectomy, presenting with severe digestive intolerance, who developed peritoneal and pulmonary tuberculosis. Standard treatment could not be administered. Therefore, treatment was initiated with isoniazid and rifampicin suppositories, and intravenous levofloxacin and amikacin, with significant remission of the digestive symptomatology. Although treatment with rifampicin suppositories has demonstrated efficacy in tuberculosis, it is rarely used in practice. This case highlights the importance of individualizing tuberculosis treatment and demonstrates that rectal administration of isoniazid and rifampicin suppositories, combined with intravenous levofloxacin and amikacin, was successfully used to treat tuberculosis in a patient with severe digestive intolerance, highlighting a potential alternative regimen when standard oral therapy is not feasible.
本文报道了一例患有胃肿瘤并接受全胃切除术的患者，该患者出现严重的消化不耐受，随后发展为腹膜和肺结核。无法进行标准治疗。因此，开始使用异烟肼和利福平栓剂以及静脉注射左氧氟沙星和阿米卡星进行治疗，消化症状有显著缓解。尽管利福平栓剂治疗结核病已显示出疗效，但在实际中很少使用。该病例突出了结核病个体化治疗的重要性，并表明直肠给药异烟肼和利福平栓剂，联合静脉注射左氧氟沙星和阿米卡星，成功用于治疗一名有严重消化不耐受的患者的结核病，凸显了在标准口服治疗不可行时的一种潜在替代方案。
