Szenci Ottó, Jerzsele Ákos, Somogyi Zoltán, Kerek Ádám, Répási Attila, Lénárt Lea, Makrai László
Department of Obstetrics and Food Animal Medicine Clinic, University of Veterinary Medicine Budapest, H-2225 Üllő, Hungary.
Department of Pharmacology and Toxicology, István utca 2, University of Veterinary Medicine Budapest, H-1078 Budapest, Hungary.
Pathogens. 2025 Apr 24;14(5):405. doi: 10.3390/pathogens14050405.
Bacteriological examination of uterine secretions provides essential information for the prevalence of bovine uterine pathogens and their influence on fertility. The objective of the present study was to determine the uterine pathogens in cases of clinical endometritis in two Holstein-Friesian dairy farms between 21 and 27 days after calving and the minimum inhibitory concentration (MIC) of 14 antimicrobials for (). Overall, the prevalence of (Farms A and B) was 46.3% and 22% ( < 0.01), respectively. In contrast, Farm B had significantly more cases ( < 0.001) of , but the distribution of uterine pathogens was similar. Regarding the prevalence of any bacteria, Farm B also had significantly more bacteria ( < 0.001) than Farm A. isolates were highly susceptible to amoxicillin, amoxicillin/clavulanic acid, tylosin, and cephalosporins, such as ceftiofur, cefquinome, and cephalexin with MIC of ≤2 μg/mL. At the same time, MIC of tulathromycin, lincomycin, and florfenicol were between 4 and 8 μg/mL and of doxycycline, enrofloxacin, oxytetracycline, and gentamicin, were between 16 and 32 μg/mL, respectively. Meanwhile, sulfamethoxazole/trimethoprim showed the highest MIC (>32 μg/mL). In summary, with high MIC against oxytetracycline, gentamicin, and sulfamethoxazole/trimethoprim were found, which calls attention to the prudent use of antibiotics.
子宫分泌物的细菌学检查为了解牛子宫病原体的流行情况及其对繁殖力的影响提供了重要信息。本研究的目的是确定两个荷斯坦 - 弗里生奶牛场产后21至27天临床子宫内膜炎病例中的子宫病原体，以及14种抗菌药物对（此处原文缺失部分内容）的最低抑菌浓度（MIC）。总体而言，（农场A和B）的患病率分别为46.3%和22%（P<0.01）。相比之下，农场B的（此处原文缺失部分内容）病例显著更多（P<0.001），但子宫病原体的分布相似。关于任何细菌的患病率，农场B的细菌也显著多于农场A（P<0.001）。（此处原文缺失部分内容）分离株对阿莫西林、阿莫西林/克拉维酸、泰乐菌素以及头孢菌素类药物（如头孢噻呋、头孢喹肟和头孢氨苄）高度敏感，MIC≤2μg/mL。同时，泰拉霉素、林可霉素和氟苯尼考的MIC在4至8μg/mL之间，强力霉素、恩诺沙星、土霉素和庆大霉素的MIC分别在16至32μg/mL之间。同时，磺胺甲恶唑/甲氧苄啶的MIC最高（>32μg/mL）。总之，发现了对土霉素、庆大霉素和磺胺甲恶唑/甲氧苄啶具有高MIC的（此处原文缺失部分内容），这提醒人们要谨慎使用抗生素。
