Sheldon I M, Bushnell M, Montgomery J, Rycroft A N
Department of Veterinary Clinical Sciences, Royal Veterinary College, Hawkshead Lane, Hatfield AL9 7TA.
Vet Rec. 2004 Sep 25;155(13):383-7. doi: 10.1136/vr.155.13.383.
The minimum inhibitory concentrations (MICs) of oxytetracycline, cephapirin, cephapirin/mecillinam, cefquinome, ceftiofur and enrofloxacin, candidate antibiotics for the principal bacteria associated with uterine infections: Escherichia coli, Arcanobacterium pyogenes and the anaerobic bacteria Fusobacterium necrophorum and Prevotella melaninogenicus, were determined by the agar dilution method. The bacteria were isolated from animals with clinical metritis and/or endometritis. For E coli, cefquinome and enrofloxacin had the lowest MIC90 and MIC50 values (< 0.06 microg/ml), and oxytetracycline and cephapirin had the highest values. For A pyogenes, oxytetracycline had the highest MIC50 value (16 microg/ml), but all the cephalosporins had values below 0.06 microg/ml. For the anaerobic bacteria, enrofloxacin and oxytetracycline had the highest MIC50 values but all the cephalosporins had values of 0.06 microg/ml or below.
采用琼脂稀释法测定了土霉素、头孢匹林、头孢匹林/美西林、头孢喹肟、头孢噻呋和恩诺沙星对与子宫感染相关的主要细菌的最低抑菌浓度（MIC），这些细菌包括大肠杆菌、化脓隐秘杆菌以及厌氧菌坏死梭杆菌和产黑色素普雷沃菌。这些细菌是从患有临床子宫内膜炎和/或子宫炎的动物中分离出来的。对于大肠杆菌，头孢喹肟和恩诺沙星的MIC90和MIC50值最低（<0.06微克/毫升），而土霉素和头孢匹林的值最高。对于化脓隐秘杆菌，土霉素的MIC50值最高（16微克/毫升），但所有头孢菌素的值均低于0.06微克/毫升。对于厌氧菌，恩诺沙星和土霉素的MIC50值最高，但所有头孢菌素的值均为0.06微克/毫升或更低。
