Zhang Jie, Liang Ziteng, Liu Fan, Wang Youchun, Huang Weijin, Nie Jianhui
Division of HIV/AIDS and Sexually-Transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing 102629, China.
State Key Laboratory of Drug Regulatory Science, National Institutes for Food and Drug Control (NIFDC), Beijing 102629, China.
Pathogens. 2025 May 6;14(5):456. doi: 10.3390/pathogens14050456.
Hepatitis E virus (HEV) is a zoonotic pathogen and the main cause of acute viral hepatitis in China, resulting in a significant burden on public health. Developing a highly efficient in vitro culture system for HEV is crucial for understanding the determinants of HEV infection in humans and other animals, the pathogenic mechanisms, as well as the screening and evaluation of antiviral drugs. In this paper, the research progress on HEV in vitro culture systems is reviewed to provide a convenient reference for further research on HEV, aiding comprehensive efforts toward the widespread prevention and control of related diseases.
戊型肝炎病毒（HEV）是一种人畜共患病原体，也是中国急性病毒性肝炎的主要病因，给公共卫生带来了沉重负担。开发一种高效的戊型肝炎病毒体外培养系统对于了解戊型肝炎病毒在人类和其他动物中的感染决定因素、致病机制以及抗病毒药物的筛选和评估至关重要。本文综述了戊型肝炎病毒体外培养系统的研究进展，为进一步研究戊型肝炎病毒提供便利参考，有助于全面开展相关疾病的广泛预防和控制工作。
