Plewa Paulina, Kiełbowski Kajetan, Mentel Oliwia, Figiel Karolina, Bakinowska Estera, Becht Rafał, Banach Bolesław, Pawlik Andrzej
Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland.
Department of Clinical Oncology, Chemotherapy and Cancer Immunotherapy, Pomeranian Medical University, 71-252 Szczecin, Poland.
Pathogens. 2025 May 21;14(5):509. doi: 10.3390/pathogens14050509.
There is a widely known relationship between certain microbes and cancer progression. For instance, is associated with the occurrence of gastric cancer, while HPV is associated with cervical and head and neck cancers. Recent studies have uncovered novel and important associations between bacterial presence and tumor formation and treatment response. Apart from the influence of the intestinal microbiome on cancer, the local activity of bacteria affects disease properties as well. Bacteria can localize within tumors in less vascularized niches. Their presence mediates the activity of signaling pathways, which contribute to tumorigenesis. Furthermore, they affect the composition of the tumor microenvironment, a highly complex structure composed of immunoregulatory cells and secreted inflammatory mediators. Recently, researchers have analyzed the properties of bacteria to develop novel anticancer strategies. The aim of this review is to discuss the latest findings regarding the relationships between bacteria and cancer and the properties of bacteria that could be used to kill cancer cells.
某些微生物与癌症进展之间存在一种广为人知的关系。例如， 与胃癌的发生有关，而人乳头瘤病毒（HPV）与宫颈癌以及头颈癌有关。最近的研究发现了细菌的存在与肿瘤形成及治疗反应之间新的重要关联。除了肠道微生物群对癌症的影响外，细菌的局部活性也会影响疾病特性。细菌可定位于血管化程度较低的肿瘤微环境中。它们的存在介导了信号通路的活性，这有助于肿瘤发生。此外，它们还会影响肿瘤微环境的组成，肿瘤微环境是一个由免疫调节细胞和分泌的炎症介质组成的高度复杂的结构。最近，研究人员分析了细菌的特性以开发新的抗癌策略。这篇综述的目的是讨论关于细菌与癌症之间关系的最新发现以及可用于杀死癌细胞的细菌特性。
