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新型方法制备的青黛的评价：对小鼠实验性溃疡性结肠炎的治疗作用

Evaluation of Indigo Naturalis Prepared Using a Novel Method: Therapeutic Effects on Experimental Ulcerative Colitis in Mice.

作者信息

Xu Xianxiang, Lin Lin, Ning Wenjie, Zhou Xinyi, Ullah Aftab, Yang Huiyong, Wu Xunxun, Diao Yong

机构信息

School of Medicine, Huaqiao University, 269 Chenghua North Road, Quanzhou 362021, China.

出版信息

Pharmaceutics. 2025 May 20;17(5):674. doi: 10.3390/pharmaceutics17050674.

DOI:10.3390/pharmaceutics17050674
PMID:40430964
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12114781/
Abstract

: Indigo naturalis (IN) is a traditional Chinese medicine concocted from medicinal plants such as (Nees) Bremek. IN has multifaceted pharmacological activities. Recent research highlights the remarkable efficacy of IN in treating ulcerative colitis (UC). This study investigates the efficacy of Indigo Naturalis prepared using a novel method (NIN) in ameliorating UC. : We have developed a new IN processing technology without the use of lime. Correspondingly, the content of active ingredients has relatively increased in NIN. In this study, dextran sulfate sodium salt (DSS) induced UC models among male KM mice, and the protective effects of NIN on UC were verified. : NIN could significantly improve weight loss, diarrhea and prolapse, bloody stools, elevated Disease Activity Index (DAI) and alleviate the colitis symptoms of mice; it could also improve the shortening of colon, disappearance of intestinal crypts, epithelial cell destruction and inflammatory infiltration caused by UC; and it could also significantly reduce the Histological Index (HI). In addition, NIN relieved the inflammatory response by decreasing the content of pro-inflammatory cytokines TNF-α and IL-1β and elevating the content of anti-inflammatory cytokines IL-10 and IL-22. It also restored the intestinal mucosal barrier by increasing the level of MUC2 protein expression at the site of colonic injury. : The significant effects of NIN on UC were verified for the first time, suggesting that NIN was worth further developing into a novel therapeutic drug and, necessarily, further safety evaluations and comparisons with traditional IN will help in the application of NIN.

摘要

青黛是一种由马蓝等药用植物炮制而成的传统中药。青黛具有多方面的药理活性。近期研究突出了青黛在治疗溃疡性结肠炎（UC）方面的显著疗效。本研究调查了采用新方法制备的青黛（NIN）改善UC的疗效。我们开发了一种不使用石灰的青黛加工新技术。相应地，NIN中活性成分的含量相对增加。在本研究中，用葡聚糖硫酸钠（DSS）诱导雄性KM小鼠建立UC模型，并验证了NIN对UC的保护作用。NIN可显著改善小鼠体重减轻、腹泻、脱肛、便血、疾病活动指数（DAI）升高的情况，并减轻结肠炎症状；还可改善UC所致的结肠缩短、肠隐窝消失、上皮细胞破坏和炎症浸润；还可显著降低组织学指数（HI）。此外，NIN通过降低促炎细胞因子TNF-α和IL-1β的含量以及提高抗炎细胞因子IL-10和IL-22的含量来减轻炎症反应。它还通过增加结肠损伤部位MUC2蛋白表达水平来恢复肠道黏膜屏障。首次验证了NIN对UC有显著作用，表明NIN值得进一步开发成一种新型治疗药物，并且，必要的进一步安全性评估以及与传统青黛的比较将有助于NIN的应用。

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本文引用的文献

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International clinical practice guideline on the use of traditional Chinese medicine for ulcerative colitis by Board of Specialty Committee of Digestive System Disease of World Federation of Chinese Medicine Societies (2023).世界中医药学会联合会消化病专业委员会国际临床实践指南：溃疡性结肠炎中医药使用（2023）。
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Mechanisms of indigo naturalis on treating ulcerative colitis explored by GEO gene chips combined with network pharmacology and molecular docking.基于 GEO 基因芯片联合网络药理学和分子对接技术探讨青黛治疗溃疡性结肠炎的作用机制。
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British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults.英国胃肠病学会成人炎症性肠病管理共识指南。
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Indigo naturalis is effective even in treatment-refractory patients with ulcerative colitis: a post hoc analysis from the INDIGO study.靛蓝天然物对溃疡性结肠炎治疗抵抗患者有效：来自 INDIGO 研究的事后分析。
J Gastroenterol. 2020 Feb;55(2):169-180. doi: 10.1007/s00535-019-01625-2. Epub 2019 Sep 16.
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Treatment with indigo naturalis for inflammatory bowel disease and other immune diseases.青黛治疗炎症性肠病及其他免疫性疾病
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