Mattucci-Schiavone L, Ferko A P
Eur J Pharmacol. 1985 Jul 17;113(2):275-8. doi: 10.1016/0014-2999(85)90746-0.
Sprague-Dawley rats received taurine intracerebroventricularly (i.c.v.) 30 min prior to ethanol (4 g/kg, i.p.). The duration of ethanol-induced sleep time was increased with taurine at doses of 7.5, 14.0 and 25.0 mumol/kg. In another experiment, TAG (a taurine antagonist, i.c.v.) was given 5 min prior to taurine (i.c.v.) and ethanol was administered 30 min later. TAG antagonized the effect of taurine to enhance ethanol-induced sleep time. These results suggest an interaction between taurine and the depressant effect of ethanol in the brain.
在腹腔注射乙醇（4克/千克）前30分钟，向Sprague-Dawley大鼠脑室内注射牛磺酸。牛磺酸剂量为7.5、14.0和25.0微摩尔/千克时，乙醇诱导的睡眠时间延长。在另一项实验中，在脑室内注射牛磺酸前5分钟给予TAG（一种牛磺酸拮抗剂，脑室内注射），30分钟后给予乙醇。TAG拮抗了牛磺酸增强乙醇诱导睡眠时间的作用。这些结果表明牛磺酸与乙醇在大脑中的抑制作用之间存在相互作用。
