持续性肛门尖锐湿疣感染中γ干扰素和分泌型免疫球蛋白A水平降低。
Interferon Gamma and Secretory Immunoglobulin A Levels Decrease in Persistent Anal Condyloma Acuminatum Infection.
作者信息
Guo Yuanli, Zhang Zi, Zhao Lipei, Ma Xiaohui, Mao Tingting, Cheng Xiaolei, Gao Qiulin, Qi Manli
机构信息
Department of Dermatology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, China.
出版信息
Ann Dermatol. 2025 Jun;37(3):140-145. doi: 10.5021/ad.24.145.
BACKGROUND
Condyloma acuminatum (CA) is a common sexually transmitted disease caused by human papillomavirus (HPV). In recent years, research on anal CA has primarily focused on treatment rather than underlying mechanisms. The mechanism of HPV persistence and recurrence in CA require further exploration. It needs multiple researches in mechanisms to focalize treatment targets.
OBJECTIVE
To investigate the relationship between intestinal mucosal immunity and the relapse of anal CA and persistent infection.
METHODS
Levels of interferon gamma (IFN-γ) and secretory immunoglobulin A (sIgA) were measured using enzyme-linked immunosorbnent assay in anal mucosal cells obtained from patients treated at Tianjin Union Medical Center from September 2022 to December 2024. All the participants signed Informed Consent and the whole plan was approved by Institutional Review Board in Tianjin Union Medical Center (No. B155).
RESULTS
The levels of IFN-γ and sIgA significantly decreased after infection, and persistent infection exhibited even lower levels. These two factors increased following treatment, reaching peak concentrations at 4 weeks before decreasing again.
CONCLUSION
These findings demonstrate a significant association between persistent anal CA infection and dysregulation of intestinal mucosal immunity.
背景
尖锐湿疣（CA）是一种由人乳头瘤病毒（HPV）引起的常见性传播疾病。近年来，关于肛门CA的研究主要集中在治疗上，而非潜在机制。CA中HPV持续存在和复发的机制需要进一步探索。需要开展多种机制研究以确定治疗靶点。
目的
探讨肠道黏膜免疫与肛门CA复发及持续感染之间的关系。
方法
采用酶联免疫吸附测定法，检测2022年9月至2024年12月在天津医科大学总医院接受治疗的患者肛门黏膜细胞中γ干扰素（IFN-γ）和分泌型免疫球蛋白A（sIgA）的水平。所有参与者均签署知情同意书，整个研究方案获得天津医科大学总医院伦理委员会批准（编号：B155）。
结果
感染后IFN-γ和sIgA水平显著降低，持续感染时水平更低。治疗后这两个因素升高，在4周时达到峰值浓度，随后再次下降。
结论
这些发现表明，肛门CA持续感染与肠道黏膜免疫失调之间存在显著关联。
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