全氟化合物乳剂交换输血对大鼠肝脏氧供及血流的影响。
Effects of exchange transfusion with perfluorochemical emulsions on hepatic oxygen supply and blood flow in the rat.
作者信息
Bizot W B, Rink R D
出版信息
Experientia. 1985 Sep 15;41(9):1127-9. doi: 10.1007/BF01951691.
PMID:4043318
Abstract
Exchange-transfusion to hematocrit 20 with isotonic perfluorochemical (PFC) emulsions containing 3% hydroxyethylstarch (HES) in rats breathing 100% oxygen produced significant reductions of hepatic PO2 and blood flow in comparison to rats hemodiluted with isotonic 3% or 6% HES solution. The results indicate that PFC and/or emulsifiers were associated with adverse effects on liver blood supply.
摘要
在吸入100%氧气的大鼠中，用含有3%羟乙基淀粉（HES）的等渗全氟化合物（PFC）乳剂进行换血，使血细胞比容达到20%，与用等渗3%或6% HES溶液进行血液稀释的大鼠相比，肝PO2和血流量显著降低。结果表明，PFC和/或乳化剂对肝脏血液供应有不良影响。
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