Wang Li-Kai, Tsai Yi-Ju, Wang Ying-Chou, Lue June-Horng, Huang Chun-Ta
Department of Anesthesiology, Chi Mei Medical Centre, Tainan, Taiwan.
School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.
CJC Open. 2025 Mar 10;7(5):606-613. doi: 10.1016/j.cjco.2025.03.003. eCollection 2025 May.
Orthopnea, a common symptom in heart failure (HF), arises from elevated pulmonary pressures and interstitial edema due to positional shifts. Remote dielectric sensing (ReDS) offers a noninvasive method to quantify lung-fluid volume. This study evaluated ReDS system measurements in response to posture changes in HF patients, and the correlation of these measurements with dyspnea severity.
This prospective observational study included both healthy volunteers and HF patients. Lung-fluid volume was measured using the ReDS system, with the patients in 3 positions-sitting, supine, and supine with elevated legs. HF patients additionally reported dyspnea levels on a visual analog scale immediately before and after ReDS measurements were made.
A total of 86 healthy volunteers and 20 HF patients were included in the study. In healthy volunteers, ReDS values modestly increased when patients changed from a sitting to a supine position (21% vs 22%; <0.001), and from being supine to supine with raised legs (22% vs 24%; <0.001). In contrast, HF patients showed significantly higher ReDS values across all positions (29%, 31%, and 34%, respectively), with more pronounced increases between positions compared to those of healthy subjects ( for interaction < 0.001). A strong correlation was observed between ReDS system measurements and dyspnea visual analog scale scores in HF patients following posture changes (Pearson's = 0.718, < 0.001).
The ReDS system effectively quantifies lung-fluid volume changes due to body-position shifts in HF patients. Its measurements correlate well with alterations in dyspnea severity, potentially offering an objective means to monitor HF symptoms. Further studies are needed to validate these findings in a larger cohort and over an extended period.
端坐呼吸是心力衰竭（HF）的常见症状，由体位改变导致肺压力升高和间质水肿引起。远程介电传感（ReDS）提供了一种非侵入性方法来量化肺液体积。本研究评估了ReDS系统测量在HF患者体位变化时的反应，以及这些测量值与呼吸困难严重程度的相关性。
这项前瞻性观察研究包括健康志愿者和HF患者。使用ReDS系统测量肺液体积，患者处于3种体位——坐位、仰卧位以及仰卧位且双腿抬高。HF患者在ReDS测量前后还需立即用视觉模拟量表报告呼吸困难程度。
该研究共纳入86名健康志愿者和20名HF患者。在健康志愿者中，当患者从坐位变为仰卧位时，ReDS值适度增加（21%对22%；<0.001），从仰卧位变为仰卧位且双腿抬高时也增加（22%对24%；<0.001）。相比之下，HF患者在所有体位下的ReDS值均显著更高（分别为29%、31%和34%），与健康受试者相比，体位之间的增加更为明显（交互作用P<0.001）。在HF患者体位改变后，观察到ReDS系统测量值与呼吸困难视觉模拟量表评分之间存在强相关性（Pearson相关系数r=0.718，P<0.001）。
ReDS系统有效地量化了HF患者体位改变引起的肺液体积变化。其测量值与呼吸困难严重程度的改变密切相关，可能提供一种监测HF症状的客观方法。需要进一步研究在更大队列和更长时间内验证这些发现。
