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股骨近端防旋髓内钉失败后行杂交全髋关节置换术的生存结果:一项中位随访10年的回顾性研究

Survival outcomes of hybrid total hip replacement following failed proximal femoral nail antirotation: a retrospective study with a median 10-year follow-up.

作者信息

Chen Yannan, Lai Zhifen, Yu Weiguang, Zeng Xianshang, Zhao Mingdong, Zhu Guangquan

机构信息

Department of Anesthesiology, Wuhan Fourth Hospital, Wuhan, China.

Department of Radiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

出版信息

Front Surg. 2025 May 13;12:1562738. doi: 10.3389/fsurg.2025.1562738. eCollection 2025.

Abstract

BACKGROUND

This retrospective study evaluates the efficacy of hybrid total hip replacement (THR) in patients aged 50 to 70 years who have experienced failures following proximal femoral nail antirotation (PFNA) procedures. By addressing a significant gap in the current medical literature-characterized by inadequate data and inconsistencies regarding the effectiveness of hybrid THRs in revision settings-this research aims to provide valuable insights into the long-term viability and clinical outcomes of hybrid THR for this demographic.

METHODS

In this retrospective observational study, we investigated 185 individuals aged 50 to 70 years who underwent hybrid THRs following PFNA procedures across two specialized Joint Surgery Centers. The primary objective of this study was to evaluate implant longevity, which was assessed using the Kaplan-Meier method, with a particular focus on revision surgeries. Additionally, we aimed to analyze secondary outcomes, including patient-reported experiences quantified by the EuroQol Visual Analogue Scale (EQ-VAS) and the Likert pain scale. Furthermore, this study sought to quantify the rates of major orthopedic complications within this patient cohort.

RESULTS

A total of 124 individuals (124 THRs) were assessed, resulting in a median follow-up duration of 10 years (range: 3-15 years). The 10-year survivorship, defined as the rate of survival without revision for any reason, was found to be 87.1% (78.5%-90.1%). Stratified survival analysis by age groups (50-60 years and 60-70 years) revealed that the 50-60-year group had significantly higher survival rates compared to the 60-70-year group ( = 0.00026). Postoperative pain scores averaged 3.0 (95% CI, 2.9-3.1), indicating a significant reduction in pain. Furthermore, patient satisfaction was high, with an average satisfaction score of 3.7 (95% CI, 3.6-3.8). The mean EQ-VAS score was 77.4 (95% CI, 76.4-78.3), reflecting favorable post-surgical health perceptions. Among the 124 patients, 13 experienced a total of 19 implant-related complications, leading to an incidence rate of 10.4% for major orthopedic complications.

CONCLUSION

Hybrid THR shows durable efficacy in patients aged 50-70 with failed PFNA, achieving high revision-free survival and improved postoperative outcomes. Younger patients (50-60 years) had superior survival, while Staphylococcus/Enterococcus infections worsened prognosis. Non-infected individuals aged 50-60 achieved optimal 10-year survival. Complications like stem loosening were reduced, but cement degradation and infection risks remain challenges. Future efforts should target age-specific protocols and infection mitigation.

摘要

背景

本回顾性研究评估了人工全髋关节置换术(THR)对年龄在50至70岁之间、股骨近端防旋髓内钉(PFNA)手术失败患者的疗效。当前医学文献存在显著空白,关于人工全髋关节置换术在翻修手术中的有效性数据不足且存在不一致性,本研究旨在填补这一空白,为该年龄段患者人工全髋关节置换术的长期可行性和临床结果提供有价值的见解。

方法

在这项回顾性观察研究中,我们调查了两个专业关节外科中心185名年龄在50至70岁之间、接受PFNA手术后行人工全髋关节置换术的患者。本研究的主要目的是评估植入物的使用寿命,采用Kaplan-Meier方法进行评估,特别关注翻修手术。此外,我们旨在分析次要结果,包括通过欧洲五维度健康量表视觉模拟评分(EQ-VAS)和李克特疼痛量表量化的患者报告体验。此外,本研究试图量化该患者队列中的主要骨科并发症发生率。

结果

共评估了124名患者(124例人工全髋关节置换术),中位随访时间为10年(范围:3至15年)。10年生存率,即无任何原因翻修的生存率,为87.1%(78.5%-90.1%)。按年龄组(50至60岁和60至70岁)进行的分层生存分析显示,50至60岁组的生存率显著高于60至70岁组(P = 0.00026)。术后疼痛评分平均为3.0(95%可信区间,2.9至3.1),表明疼痛显著减轻。此外,患者满意度较高,平均满意度评分为3.7(95%可信区间,3.6至3.8)。EQ-VAS平均评分为77.4(95%可信区间,76.4至78.3),反映了术后良好的健康感知。在124例患者中,13例共发生19例与植入物相关的并发症,主要骨科并发症发生率为10.4%。

结论

人工全髋关节置换术对PFNA失败的50至70岁患者显示出持久疗效,实现了高无翻修生存率并改善了术后结果。年轻患者(50至60岁)生存率更高,而葡萄球菌/肠球菌感染会使预后恶化。50至60岁未感染个体实现了最佳的10年生存率。柄松动等并发症有所减少,但骨水泥降解和感染风险仍然是挑战。未来的努力应针对特定年龄的方案和感染缓解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9dc/12106537/38cc0d8199d0/fsurg-12-1562738-g001.jpg

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