Deciphering the multifaceted role of in female-related cancers: implications for prognosis and therapeutic responsiveness.

BACKGROUND

Aberrant function or overactivation of exonuclease 1 () may be associated with cancer tumor development, drug resistance, and response to immunotherapy in female-related cancers.

METHODS

By analyzing RNA-sequencing data from The Cancer Genome Atlas database, combined with validation through quantitative polymerase chain reaction experiments, we explored the expression levels of in breast cancer (BRCA) cell lines and assessed its multidimensional roles in various female-related cancers.

RESULTS

Our experiments revealed elevated expression of in BRCA cell lines, consistent with the RNA-sequencing data. The high expression of is associated with poor prognosis in various female-related cancers, especially in BRCA and UCEC. It significantly correlates with clinical and pathological characteristics. In specific cancer subtypes like the basal-like subtype of BRCA, high expression is associated with a better prognosis. Genetic mutation analysis indicates a higher frequency of gene mutations in uterine sarcoma and BRCA. DNA methylation levels may play a role in the regulation of gene expression in some cancers. expression is correlated with various factors within the tumor immune microenvironment and may be associated with the sensitivity to anticancer drugs.

CONCLUSION

exhibits multidimensional roles in female-related cancers as a prognostic biomarker and potentially influences tumor immune therapy responses and drug sensitivities. Further studies are needed to fully understand the complex mechanisms underlying these associations and to explore potential therapeutic strategies targeting .