Li Zhongxian, Chen Limei, Huang Yingxin, Yan Luda, Liang Junquan, Peng Min, Zhou Yifu, Fang Jiliang, Li Mengyao, Zhou Peng
The Seventh Clinical College of Guangzhou University of Chinese Medicine, Shenzhen, China.
Shenzhen Bao'an District Traditional Chinese Medicine Hospital, Shenzhen, China.
Front Neurosci. 2025 May 13;19:1554287. doi: 10.3389/fnins.2025.1554287. eCollection 2025.
The mechanisms of Comorbid mild or moderate depression and insomnia (CmiDaI or CmoDaI) are complex, and stratification remains poorly understood.
Resting-state fMRI data were collected from 32 patients with CmiDaI, 32 with CmoDaI, and 30 healthy controls (HCs). Data were analyzed using a surface-based computational method to examine differences in amplitude of low-frequency fluctuations (ALFF) and functional connectivity (FC) across the brain.
Significant ALFF differences were found in the left dorsolateral prefrontal cortex (DLPFC) between CmiDaI and CmoDaI. Compared to CmoDaI, CmiDaI showed increased ALFF in the left DLPFC, decreased FC between left DLPFC and right superior temporal gyrus, and increased FC in the right supramarginal gyrus (SMG) and right inferior frontal gyrus (IFG). Correlation analysis suggests lower left DLPFC ALFF correlated with more severe depression and insomnia. Lower FC between left DLPFC and right IFG was associated with more severe depression, while lower FC between left DLPFC and right SMG correlated with more severe insomnia.
Our findings suggest that reduced ALFF in the left DLPFC may serve as the potential biomarker to distinguish CmiDaI from CmoDaI, and offer insights for the two disorders' treatments.
轻度或中度抑郁与失眠共病（CmiDaI 或 CmoDaI）的机制复杂，分层情况仍知之甚少。
收集了 32 例 CmiDaI 患者、32 例 CmoDaI 患者和 30 名健康对照者（HCs）的静息态功能磁共振成像（fMRI）数据。使用基于表面的计算方法分析数据，以检查全脑低频波动幅度（ALFF）和功能连接（FC）的差异。
在 CmiDaI 和 CmoDaI 之间，左侧背外侧前额叶皮质（DLPFC）存在显著的 ALFF 差异。与 CmoDaI 相比，CmiDaI 在左侧 DLPFC 中显示出 ALFF 增加，左侧 DLPFC 与右侧颞上回之间的 FC 降低，以及右侧缘上回（SMG）和右侧额下回（IFG）的 FC 增加。相关性分析表明，左侧 DLPFC 的 ALFF 较低与更严重的抑郁和失眠相关。左侧 DLPFC 与右侧 IFG 之间的 FC 较低与更严重的抑郁相关，而左侧 DLPFC 与右侧 SMG 之间的 FC 较低与更严重的失眠相关。
我们的研究结果表明，左侧 DLPFC 中 ALFF 的降低可能作为区分 CmiDaI 和 CmoDaI 的潜在生物标志物，并为这两种疾病的治疗提供见解。
