Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan.
Japan Society for the Promotion of Science, Tokyo, Japan.
Nat Commun. 2024 May 17;15(1):4201. doi: 10.1038/s41467-024-48375-1.
The dorsolateral prefrontal cortex (dlPFC) is crucial for regulation of emotion that is known to aid prevention of depression. The broader fronto-cingulo-striatal (FCS) network, including cognitive dlPFC and limbic cingulo-striatal regions, has been associated with a negative evaluation bias often seen in depression. The mechanism by which dlPFC regulates the limbic system remains largely unclear. Here we have successfully induced a negative bias in decision-making in female primates performing a conflict decision-making task, by directly microstimulating the subgenual cingulate cortex while simultaneously recording FCS local field potentials (LFPs). The artificially induced negative bias in decision-making was associated with a significant decrease in functional connectivity from cognitive to limbic FCS regions, represented by a reduction in Granger causality in beta-range LFPs from the dlPFC to the other regions. The loss of top-down directional influence from cognitive to limbic regions, we suggest, could underlie negative biases in decision-making as observed in depressive states.
背外侧前额叶皮层（dlPFC）对于情绪的调节至关重要，已知其有助于预防抑郁症。更广泛的额扣带回纹状体（FCS）网络，包括认知 dlPFC 和边缘扣带回纹状体区域，与抑郁症中经常出现的负性评价偏差有关。dlPFC 调节边缘系统的机制在很大程度上仍不清楚。在这里，我们通过直接对扣带回下脚进行微刺激，同时记录 FCS 局部场电位（LFPs），成功地在执行冲突决策任务的雌性灵长类动物中诱导了决策中的负性偏差。这种人为诱导的决策负性偏差与认知到边缘 FCS 区域之间的功能连接显著降低有关，这表现为从 dlPFC 到其他区域的β频带 LFPs 的格兰杰因果关系减少。我们认为，认知到边缘区域的自上而下的定向影响的丧失可能是抑郁状态下观察到的决策负性偏差的基础。
