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一种基于亲水性姜黄素的口服制剂在黄斑水肿治疗中的实际应用:临床经验汇总

Real-world use of a hydrophilic curcumin-based oral formulation in the management of macular oedema: a collection of clinical experiences.

作者信息

Allegrini Davide, Covello Giuseppe, Mancini Alessandra, Mancini Antonino, Mancini Maura, Romano Mary, Vecchiarelli Aldo, Romano Mario R

机构信息

Eye Clinic Humanitas Gavazzeni Castelli, Bergamo, Italy.

Department of Surgical, Medical, Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy.

出版信息

Drugs Context. 2025 May 22;14. doi: 10.7573/dic.2025-3-3. eCollection 2025.

Abstract

This is a collection of clinical experiences exploring the real-world effectiveness of a hydrophilic curcumin-based oral formulation (CHC, Diabec) in the management of macular oedema across diverse retinal conditions, including diabetic macular oedema, central serous chorioretinopathy, branch retinal vein occlusion and Irvine-Gass syndrome. Eight cases reported significant improvements in best-corrected visual acuity and central macular thickness, with complete resolution of oedema in some instances. CHC was well tolerated, with no adverse effects reported. These findings suggest that CHC is a safe and effective adjunct or standalone therapy for chronic or refractory macular oedema, enhancing anatomical and functional outcomes in real-world settings.

摘要

这是一组临床经验,探讨了一种基于亲水性姜黄素的口服制剂(CHC,Diabec)在治疗多种视网膜疾病引起的黄斑水肿方面的实际效果,这些疾病包括糖尿病性黄斑水肿、中心性浆液性脉络膜视网膜病变、视网膜分支静脉阻塞和 Irvine-Gass 综合征。8 例患者报告最佳矫正视力和中心黄斑厚度有显著改善,部分病例水肿完全消退。CHC 耐受性良好,未报告有不良反应。这些发现表明,CHC 是治疗慢性或难治性黄斑水肿的一种安全有效的辅助或独立疗法,可在现实环境中改善解剖学和功能预后。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a610/12108699/9714d7cd9042/DIC-2025-3-3_ROMANO_Figure_1.jpg

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