Allegrini Davide, Covello Giuseppe, Mancini Alessandra, Mancini Antonino, Mancini Maura, Romano Mary, Vecchiarelli Aldo, Romano Mario R
Eye Clinic Humanitas Gavazzeni Castelli, Bergamo, Italy.
Department of Surgical, Medical, Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy.
Drugs Context. 2025 May 22;14. doi: 10.7573/dic.2025-3-3. eCollection 2025.
This is a collection of clinical experiences exploring the real-world effectiveness of a hydrophilic curcumin-based oral formulation (CHC, Diabec) in the management of macular oedema across diverse retinal conditions, including diabetic macular oedema, central serous chorioretinopathy, branch retinal vein occlusion and Irvine-Gass syndrome. Eight cases reported significant improvements in best-corrected visual acuity and central macular thickness, with complete resolution of oedema in some instances. CHC was well tolerated, with no adverse effects reported. These findings suggest that CHC is a safe and effective adjunct or standalone therapy for chronic or refractory macular oedema, enhancing anatomical and functional outcomes in real-world settings.
这是一组临床经验,探讨了一种基于亲水性姜黄素的口服制剂(CHC,Diabec)在治疗多种视网膜疾病引起的黄斑水肿方面的实际效果,这些疾病包括糖尿病性黄斑水肿、中心性浆液性脉络膜视网膜病变、视网膜分支静脉阻塞和 Irvine-Gass 综合征。8 例患者报告最佳矫正视力和中心黄斑厚度有显著改善,部分病例水肿完全消退。CHC 耐受性良好,未报告有不良反应。这些发现表明,CHC 是治疗慢性或难治性黄斑水肿的一种安全有效的辅助或独立疗法,可在现实环境中改善解剖学和功能预后。