Frantsuzova S B, Antonenko L I, Krivelevich V Ia
Farmakol Toksikol. 1985 Jul-Aug;48(4):87-92.
Experiments on intact dogs and animals with an early stage of experimental cardiopulmonary insufficiency due to chronic pneumonia were made to study the action of strophanthine on the hemodynamics of the left and right ventricles and pressure in the pulmonary artery. Administration of the glycoside to animals with cardiopulmonary insufficiency increased the contractility of the right ventricle and the intensity of diastolic relaxation of both ventricles. Strophanthine was revealed to exert the prevailing effect on the cardiodynamics of the right ventricle both in intact dogs and in animals with experimentally induced pathology. Strophanthine increased pressure in the pulmonary artery, promoting the overload of the right ventricle to a less degree than convallotoxin.
对完整的狗以及患有因慢性肺炎导致实验性心肺功能不全早期阶段的动物进行了实验，以研究毒毛花苷对左右心室的血流动力学以及肺动脉压力的作用。给患有心肺功能不全的动物施用该糖苷，可增加右心室的收缩力以及两个心室舒张松弛的强度。结果显示，毒毛花苷在完整的狗和实验诱导病变的动物中，对右心室的心脏动力学均发挥主要作用。毒毛花苷会增加肺动脉压力，与铃兰毒苷相比，其促使右心室负荷过重的程度较小。
