Frantsuzova S B, Antonenko L I, Rytikova L I
Farmakol Toksikol. 1980 Nov-Dec;43(6):674-9.
The effect of convallotoxin on hemodynamics of the right and left ventricles and pressure in the pulmonary artery was studied in intact dogs and in surgical stenosis of the pulmonary trunk. In intact anesthetized dogs, convallotoxin produced changes in hemodynamics that were more pronounced in the right than in the left ventricle (decreased intraventricular pressure, increased dp/dtmax and dp/dtmin). Administration of convallotoxin ton dogs one month after pulmonary trunk stenosis without episodes of congestive heart failure did not improve the cardiohemodynamics.
研究了铃兰毒苷对完整犬以及肺动脉干手术性狭窄犬的左右心室血流动力学和肺动脉压力的影响。在完整的麻醉犬中，铃兰毒苷引起的血流动力学变化在右心室比左心室更明显（心室内压降低，dp/dtmax和dp/dtmin升高）。在肺动脉干狭窄后1个月且无充血性心力衰竭发作的犬中给予铃兰毒苷，并未改善心脏血流动力学。
