[Increased hepatocyte resistance to CC14 following the stimulation of rats with a bacterial polysaccharide].

It has been established in male Wistar rats that the uptake capacity of the reticuloendothelial system (RES) increased 5-fold 1, 3 and 7 days after prodigiozan administration (50 micrograms). This was linked with the increased hepatocyte resistance to CCl4 which reached a maximum 7 and 21 days after RES stimulation. As compared with non-stimulated animals, the resistance increase looked as a 2.7- and 3.5-fold shrinkage of the necrotic zones in the central parts of liver lobules 24 h after CCl4 poisoning and less increment of alanine aminotransferase activity in blood serum (3.5- and 3.3-fold decrease, respectively). The increased resistance continued being recordable throughout a month after prodigiozan treatment.