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乙酰胆碱可刺激培养的肌管烟碱样受体处的磷脂酰肌醇周转。

Acetylcholine stimulates phosphatidylinositol turnover at nicotinic receptors of cultured myotubes.

作者信息

Adamo S, Zani B M, Nervi C, Senni M I, Molinaro M, Eusebi F

出版信息

FEBS Lett. 1985 Oct 7;190(1):161-4. doi: 10.1016/0014-5793(85)80449-x.

DOI:10.1016/0014-5793(85)80449-x
PMID:4043395
Abstract

Acetylcholine treatment of [3H]inositol pre-labelled cultured chick embryo myotubes results in the stimulation of phosphatidylinositol breakdown, as shown by the measurement of inositol-1-phosphate accumulating in the presence of lithium. The described effect is dependent on agonist concentration and incubation time, and is inhibited by tubocurarine and alpha-bungarotoxin. The activation of phosphatidylinositol breakdown by acetylcholine at extrajunctional nicotinic receptors is likely to be involved in the modulation of the functional activity of the receptor.

摘要

用乙酰胆碱处理预先用[³H]肌醇标记的培养鸡胚肌管，会刺激磷脂酰肌醇的分解，这可通过在锂存在的情况下测量积累的肌醇-1-磷酸来表明。所描述的效应取决于激动剂浓度和孵育时间，并被筒箭毒碱和α-银环蛇毒素抑制。乙酰胆碱在接头外烟碱型受体处激活磷脂酰肌醇分解可能参与受体功能活性的调节。

相似文献

1
Acetylcholine stimulates phosphatidylinositol turnover at nicotinic receptors of cultured myotubes.乙酰胆碱可刺激培养的肌管烟碱样受体处的磷脂酰肌醇周转。
FEBS Lett. 1985 Oct 7;190(1):161-4. doi: 10.1016/0014-5793(85)80449-x.
2
Oxotremorine acts as a partial nicotinic agonist on cultured chick myotubes.氧化震颤素对培养的鸡肌管起部分烟碱样激动剂的作用。
Acta Pharmacol Toxicol (Copenh). 1985 Nov;57(5):317-21. doi: 10.1111/j.1600-0773.1985.tb00051.x.
3
Acetylcholine differentially affects intracellular calcium via nicotinic and muscarinic receptors on the same population of neurons.乙酰胆碱通过同一群神经元上的烟碱型受体和毒蕈碱型受体对细胞内钙产生不同影响。
J Biol Chem. 1995 Jun 16;270(24):14366-75. doi: 10.1074/jbc.270.24.14366.
4
Induction of phosphorylation and cell surface redistribution of acetylcholine receptors by phorbol ester and carbamylcholine in cultured chick muscle cells.佛波酯和氨甲酰胆碱对培养的鸡肌细胞中乙酰胆碱受体磷酸化及细胞表面重新分布的诱导作用。
J Cell Biol. 1988 Sep;107(3):1139-45. doi: 10.1083/jcb.107.3.1139.
5
The breakdown of phosphatidylinositol in myoblasts stimulated to fuse by the addition of Ca2+.在通过添加Ca2+刺激融合的成肌细胞中磷脂酰肌醇的分解。
Biochem J. 1982 Mar 15;202(3):723-9. doi: 10.1042/bj2020723.
6
Chick sympathetic neurons develop receptors for alpha-bungarotoxin in vitro, but the toxin does not block nicotinic receptors.鸡交感神经元在体外发育出针对α-银环蛇毒素的受体，但该毒素并不阻断烟碱样受体。
Brain Res. 1978 Oct 6;154(1):83-93. doi: 10.1016/0006-8993(78)91053-3.
7
Acetylcholine increases the breakdown of triphosphoinositide of rabbit iris muscle prelabelled with [32P] phosphate.乙酰胆碱可增加预先用[32P]磷酸盐标记的兔虹膜肌三磷酸肌醇的分解。
Biochem J. 1977 Jan 15;162(1):61-73. doi: 10.1042/bj1620061.
8
Phosphorylation of phosphatidylinositol associated with the nicotinic acetylcholine receptor of Torpedo californica.与加州电鳐烟碱型乙酰胆碱受体相关的磷脂酰肌醇的磷酸化作用。
Biochem Biophys Res Commun. 1987 Sep 30;147(3):1251-8. doi: 10.1016/s0006-291x(87)80205-x.
9
Acetylcholine causes an increase in the hydrolysis of triphosphoinositide pre-labelled with [32P]phosphate or [3H]myo-inositol and a corresponding increase in the labelling of phosphatidylinositol and phosphatidic acid in rabbit iris muscle.乙酰胆碱可使预先用[32P]磷酸盐或[3H]肌醇标记的三磷酸肌醇的水解增加，并使兔虹膜肌肉中磷脂酰肌醇和磷脂酸的标记相应增加。
Biochem Soc Trans. 1976;4(2):317-21. doi: 10.1042/bst0040317.
10
Nicotinic stimulation of polyphosphoinositide turnover in rat adrenal medulla slices.烟碱对大鼠肾上腺髓质切片中多磷酸肌醇代谢的刺激作用。
Pharmazie. 1987 May;42(5):341-4.

引用本文的文献

1
Involvement of phospholipase Cgamma1 in mouse egg activation induced by a truncated form of the C-kit tyrosine kinase present in spermatozoa.磷脂酶Cγ1参与精子中存在的截短形式C-kit酪氨酸激酶诱导的小鼠卵母细胞激活。
J Cell Biol. 1998 Aug 24;142(4):1063-74. doi: 10.1083/jcb.142.4.1063.
2
Ca2+ signalling pathways activated by acetylcholine in mouse C2C12 myotubes.乙酰胆碱在小鼠C2C12肌管中激活的Ca2+信号通路。
Pflugers Arch. 1994 Oct;428(3-4):340-5. doi: 10.1007/BF00724516.
3
Postsynaptic effects of the phorbol ester TPA on frog end-plates.
佛波酯TPA对蛙终板的突触后效应。
Pflugers Arch. 1986 Oct;407(4):409-13. doi: 10.1007/BF00652626.
4
Induction of phosphorylation and cell surface redistribution of acetylcholine receptors by phorbol ester and carbamylcholine in cultured chick muscle cells.佛波酯和氨甲酰胆碱对培养的鸡肌细胞中乙酰胆碱受体磷酸化及细胞表面重新分布的诱导作用。
J Cell Biol. 1988 Sep;107(3):1139-45. doi: 10.1083/jcb.107.3.1139.
5
Regulation of nicotinic acetylcholine receptors by protein phosphorylation.蛋白质磷酸化对烟碱型乙酰胆碱受体的调控
Mol Neurobiol. 1988 Summer;2(2):91-124. doi: 10.1007/BF02935341.
6
Activity-dependent regulation of gene expression in muscle and neuronal cells.肌肉和神经细胞中基因表达的活性依赖性调控。
Mol Neurobiol. 1989 Spring-Summer;3(1-2):1-53. doi: 10.1007/BF02935587.
7
Activity and regulation of calcium-, phospholipid-dependent protein kinase in differentiating chick myogenic cells.分化中的鸡成肌细胞中钙磷脂依赖性蛋白激酶的活性与调节
J Cell Biol. 1989 Jan;108(1):153-8. doi: 10.1083/jcb.108.1.153.
8
Calcitonin gene-related peptide enhances the rate of desensitization of the nicotinic acetylcholine receptor in cultured mouse muscle cells.降钙素基因相关肽可提高培养的小鼠肌肉细胞中烟碱型乙酰胆碱受体的脱敏速率。
Proc Natl Acad Sci U S A. 1988 Aug;85(15):5728-32. doi: 10.1073/pnas.85.15.5728.
9
Acetylcholine regulation of nicotinic receptor channels through a putative G protein in chick myotubes.通过鸡肌管中一种假定的G蛋白实现乙酰胆碱对烟碱样受体通道的调节。
J Physiol. 1987 Dec;393:635-45. doi: 10.1113/jphysiol.1987.sp016845.
10
Acetylcholine induces voltage-independent increase of cytosolic calcium in mouse myotubes.乙酰胆碱可诱导小鼠肌管中胞质钙的电压非依赖性增加。
Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10069-73. doi: 10.1073/pnas.88.22.10069.