Ruszala Brandon M, Schieber Marc H
Department of Biomedical Engineering, University of Rochester, Rochester, NY 14627, USA.
Department of Neurology, University of Rochester, Rochester, NY 14642, USA; Department of Neuroscience, University of Rochester, Rochester, NY 14642, USA.
Cell Rep. 2025 May 27;44(5):115664. doi: 10.1016/j.celrep.2025.115664. Epub 2025 May 19.
Although control of movement involves many cortical association areas, bidirectional brain-machine interfaces (BMIs) typically decode movement intent from the motor cortex and deliver feedback information to the primary somatosensory cortex (S1). Compared to the S1, the parietal and premotor areas encode more complex information about object properties, hand pre-shaping, and reach trajectories. BMIs therefore might deliver richer information to those cortical association areas than to primary areas. Here, we investigated whether instructions for a center-out task could be delivered via intracortical microstimulation (ICMS) in the anterior intraparietal area (AIP), dorsal posterior parietal cortex (dPPC), or dorsal premotor cortex (PMd) as well as the ventral premotor cortex (PMv) and S1. Two monkeys successfully learned to use AIP, PMv, or S1-ICMS instructions, but neither learned to use dPPC- or PMd-ICMS instructions. The AIP, PMv, and S1 may thus be effective cortical territory for delivering information to the brain, whereas the dPPC or PMd may be comparatively ineffective.
尽管运动控制涉及许多皮质联合区，但双向脑机接口（BMI）通常从运动皮层解码运动意图，并将反馈信息传递到初级体感皮层（S1）。与S1相比，顶叶和运动前区编码有关物体属性、手部预塑形和伸展轨迹的更复杂信息。因此，BMI可能向那些皮质联合区传递比向初级区域更丰富的信息。在这里，我们研究了中心向外任务的指令是否可以通过皮层内微刺激（ICMS）在前顶内区（AIP）、顶叶后背部皮层（dPPC）或背侧运动前皮层（PMd）以及腹侧运动前皮层（PMv）和S1中传递。两只猴子成功学会使用AIP、PMv或S1-ICMS指令，但都没有学会使用dPPC-或PMd-ICMS指令。因此，AIP、PMv和S1可能是向大脑传递信息的有效皮质区域，而dPPC或PMd可能相对无效。
