Bazzano Marilena, Laus Fulvio, Cerquetella Matteo, Spaterna Andrea, Marchegiani Andrea
School of Biosciences and Veterinary Medicine, University of Camerino, Matelica, Italy.
PLoS One. 2025 May 28;20(5):e0325191. doi: 10.1371/journal.pone.0325191. eCollection 2025.
Phytocannabinoids have the potential to lower intraocular pressure in both normal and glaucomatous eyes and they have been tested in different animal species, but not in the horse. The present paper describes the tonometric curve of healthy adult Italian Saddle horses after oral administration of cannabidiol oil (CBD).
CBD 20% was administered orally (oily solution) at the dose of 1 mg/kg to 8 adult horses and intraocular pressure (IOP) was evaluated by tonometric curve. Data were then compared to those of the same horses obtained the day before (blank) CBD administration.
15 minutes after CBD administration, IOP (time zero 27.3 ± 2.1 mmHg right eye; 24.6 ± 2.3 mmHg left eye) started to decrease (19.5 ± 5.2 mmHg right eye; 20.8 ± 2.4 mmHg left eye) and 1 hour later CBD it reached the minimum level in all horses (11.4 ± 7.5 mmHg right eye; 9.5 ± 5.8 mmHg left eye), remaining statistically significantly lower than normal values for the entire observation period (8 hours; 12.0 ± 7.9 mmHg right eye; 11.9 ± 7.8 mmHg left eye).
CBD 20% was effective to significantly reduce IOP in healthy adult Italian Saddle horses and may be an effective hypotensive agent to be implemented in case of primary or secondary glaucoma.
植物大麻素有可能降低正常眼和青光眼眼中的眼压，并且已经在不同动物物种中进行了测试，但未在马身上进行测试。本文描述了健康成年意大利鞍马口服大麻二酚油（CBD）后的眼压曲线。
将20%的CBD以1mg/kg的剂量口服（油溶液）给予8匹成年马，并通过眼压曲线评估眼压（IOP）。然后将数据与这些马在口服CBD前一天（空白）获得的数据进行比较。
口服CBD后15分钟，眼压（右眼零时间为27.3±2.1mmHg；左眼为24.6±2.3mmHg）开始下降（右眼为19.5±5.2mmHg；左眼为20.8±2.4mmHg），1小时后，所有马匹的眼压达到最低水平（右眼为11.4±7.5mmHg；左眼为9.5±5.8mmHg），在整个观察期（8小时）内仍显著低于正常值（右眼为12.0±7.9mmHg；左眼为11.9±7.8mmHg）。
20%的CBD可有效显著降低健康成年意大利鞍马的眼压，可能是一种有效的降压药物，可用于原发性或继发性青光眼。
