Iida M, Yao T, Itoh H, Watanabe H, Kohrogi N, Shigematsu A, Iwashita A, Fujishima M
Gastroenterology. 1985 Nov;89(5):1021-5. doi: 10.1016/0016-5085(85)90203-3.
In order to study the natural history of fundic gland polyposis, 23 patients with familial adenomatosis coli/Gardner's syndrome were examined over a follow-up period ranging from 17 mo to 13 yr (average 6 yr). Examinations included gastric radiography and endoscopy with biopsy. Fundic gland polyps were found in 10 individuals. The size and number of polyps varied considerably. During the follow-up period, there was an increase in number or size of polyps, or both, in 5 patients (aged 8-27 yr), a decrease or disappearance in 2 patients (aged 36 and 41 yr), an initial decrease or disappearance followed by a late-occurring increase in 2 patients (aged 28 and 35 yr), In addition, malignant or adenomatous changes of fundic gland polyps were not observed in any patient. Therefore, fundic gland polyposis in patients with familial adenomatosis coli/Gardner's syndrome may appear as early as 8 yr of age. In some patients there is a gradual increase in number and size of polyps, whereas in others, polyp proliferation ceases and polyps may even decrease in number and size. Our findings indicate that the fundic gland polyposis does not require prophylactic surgery and that careful periodic follow-up should suffice.
为研究胃底腺息肉病的自然病程，我们对23例家族性腺瘤性息肉病/加德纳综合征患者进行了为期17个月至13年（平均6年）的随访检查。检查包括胃造影和内镜活检。10例患者发现有胃底腺息肉。息肉的大小和数量差异很大。在随访期间，5例患者（年龄8 - 27岁）息肉数量或大小增加，或两者均增加；2例患者（年龄36岁和41岁）息肉减少或消失；2例患者（年龄28岁和35岁）息肉最初减少或消失，随后后期增加。此外，未观察到任何患者的胃底腺息肉发生恶性或腺瘤样改变。因此，家族性腺瘤性息肉病/加德纳综合征患者的胃底腺息肉病可能早在8岁时就出现。在一些患者中，息肉的数量和大小逐渐增加，而在另一些患者中，息肉增殖停止，甚至息肉数量和大小可能减少。我们的研究结果表明，胃底腺息肉病不需要预防性手术，定期仔细随访就足够了。
