Iida M, Yao T, Itoh H, Watanabe H, Matsui T, Iwashita A, Fujishima M
Department of Internal Medicine II, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Cancer. 1988 Feb 1;61(3):605-11. doi: 10.1002/1097-0142(19880201)61:3<605::aid-cncr2820610331>3.0.co;2-l.
The natural history of gastric adenomas was studied in 26 patients with familial adenomatosis coli (FAC)/Gardner's syndrome. The patients were followed for an average of 6.8 years (1 year, 5 months to 15 years 4 months) and examined repeatedly using gastric radiography, endoscopy, and biopsy. Gastric adenomas were present in 13 (50%). During the follow-up period, there was a new appearance of gastric adenomas in six patients but no distinct change in number, size, and histologic features in the remaining seven patients. In a 51-year-old man, an antral adenoma that measured 13 mm in diameter and had an irregular central depression did not change in size or morphology during 4 years and 1 month, but malignant change was evident at the time of endoscopic biopsy. The findings indicate that in patients with this disease, gastric adenomas require careful repeated follow-up examinations using endoscopic biopsy and, if feasible, endoscopic removal is recommended.
对26例家族性腺瘤性结肠息肉病（FAC）/加德纳综合征患者的胃腺瘤自然史进行了研究。患者平均随访6.8年（1年5个月至15年4个月），并多次使用胃造影、内镜检查和活检进行检查。13例（50%）存在胃腺瘤。在随访期间，6例患者出现了新的胃腺瘤，但其余7例患者的腺瘤数量、大小和组织学特征无明显变化。一名51岁男性的胃窦腺瘤直径为13 mm，中央有不规则凹陷，在4年1个月内大小和形态未发生变化，但在内镜活检时发现有恶变。研究结果表明，对于患有这种疾病的患者，胃腺瘤需要使用内镜活检进行仔细的反复随访检查，并且如果可行，建议进行内镜切除。
