Li Kangming, Chen Shizhong, Hu Yanan, Qi Chunmei
Department of Cardiology, The Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Graduate School, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Front Cardiovasc Med. 2025 May 14;12:1506603. doi: 10.3389/fcvm.2025.1506603. eCollection 2025.
The rising incidence of cardiovascular diseases (CVD) in the elderly highlights the need for effective preventive strategies. Recent studies suggest that obesity, through metabolic factors, contributes to the development of CVD. This study aims to explore how body roundness index (BRI) levels affect the occurrence of CVD using data from the National Health and Nutrition Examination Survey (NHANES) (2003-2016), to better understand the role of obesity in CVD prevention and management.
The study analyzed data from 3,584 NHANES participants over seven cycles (2003-2016), dividing them into three groups (T1, T2, T3) based on BRI values. Univariate and multivariate regression analyses were used to assess the association between BRI and atherogenic index of plasma (AIP) levels with the occurrence of CVD. The mediating effect of AIP on BRI and CVD was also analyzed.
Compared to the lowest tertile of BRI, participants with higher BRI levels had a higher proportion of females, smokers, drinkers, and individuals with lower educational attainment. Poverty-income ratio (PIR) and AIP levels were significantly higher, and the prevalence of CVD was also higher. BRI and AIP were both independent risk factors for CVD, with AIP having a significant mediating effect between BRI and CVD.
BRI levels significantly impact the occurrence of CVD through AIP mediation.
老年人心血管疾病（CVD）发病率不断上升，凸显了有效预防策略的必要性。近期研究表明，肥胖通过代谢因素促使心血管疾病的发生。本研究旨在利用美国国家健康与营养检查调查（NHANES）（2003 - 2016年）的数据，探讨身体圆润度指数（BRI）水平如何影响心血管疾病的发生，以便更好地理解肥胖在心血管疾病预防和管理中的作用。
该研究分析了七个周期（2003 - 2016年）中3584名NHANES参与者的数据，根据BRI值将他们分为三组（T1、T2、T3）。采用单因素和多因素回归分析来评估BRI与血浆致动脉粥样硬化指数（AIP）水平与心血管疾病发生之间的关联。还分析了AIP在BRI与心血管疾病之间的中介作用。
与BRI最低三分位数相比，BRI水平较高的参与者中女性、吸烟者、饮酒者以及教育程度较低者的比例更高。贫困收入比（PIR）和AIP水平显著更高，心血管疾病的患病率也更高。BRI和AIP都是心血管疾病的独立危险因素，AIP在BRI与心血管疾病之间具有显著的中介作用。
BRI水平通过AIP中介显著影响心血管疾病的发生。
