Wong Harroun Valdimir T, Cañal Johanna Patricia A
Division of Radiation Oncology, Department of Radiology, Philippine General Hospital, University of the Philippines Manila.
Department of Radiology, Asian Hospital and Medical Center.
Acta Med Philipp. 2025 Apr 30;59(5):75-81. doi: 10.47895/amp.vi0.7516. eCollection 2025.
Gorham-Stout disease is a rare osteolytic disorder with an unclear pathophysiology. It presents as lesions characterized by the loss of the bony matrix and the proliferation of malformed vasculature. At present, there are no gold-standard diagnostic evaluation protocols and it is diagnosed through a mixture of clinical, histopathologic, and radiographic findings. We report a case of a 19-year-old female with Gorham-Stout disease presenting with an 8-year progressive soft tissue mass in the mandible. Extensive osteolysis of the mandible with clustering of the mandibular dentition is noted on computed tomography (CT) imaging. Her case was discussed in a multidisciplinary conference and her treatment was radiotherapy followed by surgery ± reconstruction. We used a CT-based three-dimensional planning technique to give 40 Gy over 20 treatment sessions to the involved areas. Post treatment, a repeat CT was done at six weeks to reassess for disease progression or stabilization, followed by surgical excision. As of 31 October 2021, no evidence of recurrence is noted 48 months after treatment. Arriving at a definitive diagnosis with Gorham-Stout disease is challenging and a multidisciplinary team approach can help determine the treatment choice with best outcomes.
戈勒姆-斯托特病是一种罕见的骨质溶解症，其病理生理学尚不清楚。它表现为以骨基质丧失和畸形血管增生为特征的病变。目前，尚无金标准的诊断评估方案，而是通过临床、组织病理学和影像学检查结果综合诊断。我们报告一例19岁女性戈勒姆-斯托特病患者，其下颌骨出现一个8年的进行性软组织肿块。计算机断层扫描（CT）成像显示下颌骨广泛骨质溶解，下颌牙列聚集。该病例在多学科会议上进行了讨论，其治疗方法是先进行放疗，然后进行手术±重建。我们使用基于CT的三维规划技术，在20个治疗疗程中对受累区域给予40 Gy的剂量。治疗后，在六周时进行重复CT检查，以重新评估疾病进展或稳定情况，随后进行手术切除。截至2021年10月31日，治疗后48个月未发现复发迹象。明确诊断戈勒姆-斯托特病具有挑战性，多学科团队方法有助于确定最佳治疗方案。
