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结直肠癌肿瘤微环境的研究热点与前沿：一项2014年至2024年的文献计量学研究

Research hotspots and frontiers in the tumor microenvironment of colorectal cancer: a bibliometric study from 2014 to 2024.

作者信息

He Xinran, Xie Tingyi, Shi Li, Kuang Xuyi, Li Lei, Shang Xingyu, Fu Bo

机构信息

The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China.

Department of Nephrology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China.

出版信息

Front Oncol. 2025 Feb 5;15:1525280. doi: 10.3389/fonc.2025.1525280. eCollection 2025.

DOI:10.3389/fonc.2025.1525280
PMID:39975599
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11835677/
Abstract

BACKGROUND: Colorectal cancer (CRC) is the second leading cause of cancer deaths globally, which poses a heavy burden on our healthcare and economy. In recent years, increasing researches suggest that the tumor microenvironment (TME) influences cancer onset, progression, metastasis, and treatment. This has become a popular direction for researching and attacking cancer. However, to date, there is no bibliometric analysis of colorectal cancer and tumor microenvironment from 2014 to 2024. This study aims to provide a comprehensive picture of the current research status, hotspots, and future trends in this field from a bibliometric perspective. METHODS: In this study, the publications about colorectal cancer and tumor microenvironment from 2014 to 2024 were searched based on the Web of Science Core Collection database. Then we analyzed and visualized the data using CiteSpace, VOSviewer, bibliometrix package, and Microsoft Excel 2019. RESULTS: A total of 748 publications were included in our study, and the number of publications entered a period of rapid growth after 2019. China and the United States are the major research and collaboration centers in this field. Elkord, Eyad is the most prolific author, and Frontiers in Immunology is the journal that published the most papers on the TME of CRC. In addition, keyword and cluster analysis showed that immune checkpoint inhibitors, cancer-associated fibroblasts, macrophage polarization, intestinal microbiota, colorectal cancer liver metastasis, drug resistance, scRNA-seq, etc. may be the research hotspots and trends in this field. CONCLUSIONS: Colorectal cancer and tumor microenvironment research is in the developmental stage, and strengthening international cooperation can help to drive this field forward. The main components and signaling in TME, CRC immunotherapy, colorectal cancer liver metastasis, and new research techniques are the hot research directions in this domain. Our findings will provide scholars with an up-to-date perspective on the current state of research, hotspots, and future trends in this field.

摘要

背景：结直肠癌（CRC）是全球癌症死亡的第二大主要原因，给我们的医疗保健和经济带来了沉重负担。近年来，越来越多的研究表明，肿瘤微环境（TME）影响癌症的发生、发展、转移和治疗。这已成为癌症研究和攻克的一个热门方向。然而，迄今为止，尚无对2014年至2024年结直肠癌与肿瘤微环境的文献计量分析。本研究旨在从文献计量学角度全面呈现该领域当前的研究现状、热点及未来趋势。 方法：本研究基于科学网核心合集数据库检索了2014年至2024年关于结直肠癌和肿瘤微环境的出版物。然后我们使用CiteSpace、VOSviewer、bibliometrix软件包和Microsoft Excel 2019对数据进行分析和可视化处理。 结果：我们的研究共纳入748篇出版物，2019年后出版物数量进入快速增长期。中国和美国是该领域主要的研究与合作中心。埃亚德·埃尔科德是发文量最多的作者，《免疫学前沿》是发表关于CRC肿瘤微环境论文最多的期刊。此外，关键词和聚类分析表明，免疫检查点抑制剂、癌症相关成纤维细胞、巨噬细胞极化、肠道微生物群、结直肠癌肝转移、耐药性、单细胞RNA测序等可能是该领域的研究热点和趋势。 结论：结直肠癌与肿瘤微环境研究正处于发展阶段，加强国际合作有助于推动该领域向前发展。肿瘤微环境中的主要成分和信号通路、CRC免疫治疗、结直肠癌肝转移以及新的研究技术是该领域的热门研究方向。我们的研究结果将为学者们提供该领域当前研究状况、热点及未来趋势的最新视角。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/744d/11835677/6864d90738c5/fonc-15-1525280-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/744d/11835677/9d405c1d983e/fonc-15-1525280-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/744d/11835677/313b3a3ea81f/fonc-15-1525280-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/744d/11835677/58bcccc4b2df/fonc-15-1525280-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/744d/11835677/f79004e46d17/fonc-15-1525280-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/744d/11835677/6864d90738c5/fonc-15-1525280-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/744d/11835677/9d405c1d983e/fonc-15-1525280-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/744d/11835677/313b3a3ea81f/fonc-15-1525280-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/744d/11835677/58bcccc4b2df/fonc-15-1525280-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/744d/11835677/f79004e46d17/fonc-15-1525280-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/744d/11835677/6864d90738c5/fonc-15-1525280-g005.jpg

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本文引用的文献

[1]
Multi-stage mechanisms of tumor metastasis and therapeutic strategies.

Signal Transduct Target Ther. 2024-10-11

[2]
Exosomal miR-106a-5p from highly metastatic colorectal cancer cells drives liver metastasis by inducing macrophage M2 polarization in the tumor microenvironment.

J Exp Clin Cancer Res. 2024-10-9

[3]
Colorectal cancer: Recent advances in management and treatment.

World J Clin Oncol. 2024-9-24

[4]
Research trends in lung cancer and the tumor microenvironment: a bibliometric analysis of studies published from 2014 to 2023.

Front Oncol. 2024-7-31

[5]
Research hotspots and frontiers of neoadjuvant therapy in triple-negative breast cancer: a bibliometric analysis of publications between 2002 and 2023.

Int J Surg. 2024-8-1

[6]
Monocyte/Macrophage-Mediated Transport of Dual-Drug ZIF Nanoplatforms Synergized with Programmed Cell Death Protein-1 Inhibitor Against Microsatellite-Stable Colorectal Cancer.

Adv Sci (Weinh). 2024-10

[7]
Mapping Theme Trends and Research Frontiers in Dexmedetomidine Over Past Decade: A Bibliometric Analysis.

Drug Des Devel Ther. 2024

[8]
Immunomodulatory molecules in colorectal cancer liver metastasis.

Cancer Lett. 2024-8-28

[9]
Current and Emerging Treatment Paradigms in Colorectal Cancer: Integrating Hallmarks of Cancer.

Int J Mol Sci. 2024-6-26

[10]
Current and Future Trends of Colorectal Cancer Treatment: Exploring Advances in Immunotherapy.

Cancers (Basel). 2024-5-24

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