Zhou Juan, Nie Min, Song Zixia, Shen Xing
Department of Pediatrics, Bazhong Central Hospital, Bazhong, Sichuan, China.
Department of Pediatrics, Sichuan Clinical Research Center for Birth Defects, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Front Pediatr. 2025 May 14;13:1534687. doi: 10.3389/fped.2025.1534687. eCollection 2025.
The objective of this study was to investigate the health-related quality of life (HRQOL) in children diagnosed with IgAV and explore factors influencing it, aiming to provide insights for rehabilitation of these children.
This study enrolled 114 children diagnosed with IgAV at Bazhong Central Hospital between January 2019 and January 2023. 51 healthy children undergoing health check-ups during the same period were enrolled in control group. Data on sociodemographic and clinical characteristics, as well as health-related quality of life scores, were collected. The Pediatric Quality of Life Inventory Measurement Models 4.0 (PedsQL™ 4.0) was utilized to assess the HRQOL of these children and to explore correlations among different dimensions of quality of life. General linear regression models were applied to analysis of influencing factors of the HRQOL of children with IgAV.
The health-related quality of life scores in all dimensions for children with IgAV were lower compared to those of healthy children. Recurrence of IgAV was negatively correlated with all dimension scores and the total HRQOL score ( < 0.05). Children with exercise-induced onset showed lower physiological functioning scores compared to those without exercise-induced onset. Emotional functioning scores were lower in children with self-funded medical care compared to those with Medicare. Children with medication duration longer than 1 week exhibited higher social functioning scores.
The HRQOL of IgAV children is lower than that of healthy children. Relapse, exercise, the payment method and regularity of medications affect children's health-related quality of life.
本研究旨在调查诊断为免疫球蛋白A肾病（IgAV）的儿童的健康相关生活质量（HRQOL），并探讨影响其的因素，旨在为这些儿童的康复提供见解。
本研究纳入了2019年1月至2023年1月期间在巴中市中心医院诊断为IgAV的114名儿童。同期进行健康体检的51名健康儿童纳入对照组。收集社会人口学和临床特征数据以及健康相关生活质量得分。采用儿童生活质量量表测量模型4.0（PedsQL™ 4.0）评估这些儿童的HRQOL，并探讨生活质量不同维度之间的相关性。应用一般线性回归模型分析IgAV儿童HRQOL的影响因素。
与健康儿童相比，IgAV儿童各维度的健康相关生活质量得分均较低。IgAV复发与所有维度得分及总HRQOL得分呈负相关（<0.05）。运动诱发起病的儿童与非运动诱发起病的儿童相比，生理功能得分较低。自费医疗的儿童与享受医疗保险的儿童相比，情感功能得分较低。用药持续时间超过1周的儿童社会功能得分较高。
IgAV儿童的HRQOL低于健康儿童。复发、运动、支付方式和用药规律影响儿童的健康相关生活质量。
