Peng Haibo, Xu Ningyue, Gao Dong, Tan Huigang, Ren Tao
Department of Oncology, School of Clinical Medicine and The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610500, P.R. China.
Clinical Key Speciality (Oncology Department) of Sichuan Province, Chengdu, Sichuan 610500, P.R. China.
Oncol Lett. 2025 May 14;30(1):344. doi: 10.3892/ol.2025.15090. eCollection 2025 Jul.
Radiotherapy (RT) is an established viable treatment for cervical cancer across all clinical stages. However, the therapeutic ratio of conventional techniques remains suboptimal due to the anatomical proximity of the cervix to critical pelvic organs. The current study presents a case of pathological complete response (pCR) achieved exclusively through preoperative online adaptive RT (oART) guided by fan beam computed tomography (FBCT). A 54-year-old woman presenting with irregular vaginal bleeding was diagnosed with a cervical mass via pelvic imaging. Subsequent histopathological biopsy confirmed invasive papillary squamous cell carcinoma. Preoperative evaluation, supplemented by laboratory and imaging studies, ruled out distant metastases. The patient underwent fractionated oART using a CT-linear accelerator platform. Post-treatment imaging demonstrated complete resolution of the lesion, and surgical histopathology revealed no residual malignancy. This case highlights the feasibility, safety and dosimetric precision of FBCT-guided oART in cervical cancer. The pCR achieved in this case indicates that oART has the potential to improve the treatment of cervical cancer.
放射治疗（RT）是所有临床分期宫颈癌的一种既定可行治疗方法。然而，由于宫颈与盆腔关键器官在解剖位置上接近，传统技术的治疗比仍不理想。本研究报告了一例仅通过术前在线自适应放疗（oART）并由扇形束计算机断层扫描（FBCT）引导而实现病理完全缓解（pCR）的病例。一名54岁出现不规则阴道出血的女性经盆腔成像诊断为宫颈肿块。随后的组织病理学活检证实为浸润性乳头状鳞状细胞癌。术前评估辅以实验室和影像学检查，排除了远处转移。患者使用CT直线加速器平台接受了分次oART。治疗后成像显示病变完全消退，手术组织病理学显示无残留恶性肿瘤。该病例突出了FBCT引导的oART在宫颈癌治疗中的可行性、安全性和剂量测定精度。本病例中实现的pCR表明oART有改善宫颈癌治疗的潜力。
