Nguyen Hau Van Vy, Nguyen Bang Van, Nguyen Xuan Thi, Pham Linh Nguyen Tuyen, Nguyen Thoi Thi Ngoc, Vo Trang Thanh, Le Tam Thi, Le Binh Trong, Nguyen Thuy Hai, Le Chi Van
Center of Endocrinology and Diabetes, Family Hospital, Da Nang, Vietnam.
Department of Internal Medicine, Hue University of Medicine and Pharmacy, Hue University, Hue City, Vietnam.
Asian Pac J Cancer Prev. 2025 May 1;26(5):1563-1569. doi: 10.31557/APJCP.2025.26.5.1563.
This retrospective study evaluated the effectiveness of ultrasound-guided fine-needle aspiration cytology (US-FNAc) for diagnosing thyroid nodules less than 10mm and explored the correlation between the TIRADS classification and US-FNAc reports.
This analysis of 344 patients with 407 thyroid nodules less than 10mm was conducted from June 2022 to July 2023 at the Centre of Endocrinology and Diabetes, Danang Family hospital, Danang, Vietnam. US-FNAc was performed on all nodules, and cytology was reported according to The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of US-FNAc were calculated. Correlation between cytology and TIRADS classification was assessed using Spearman's correlation.
Adequate specimens were obtained in 81% of thyroid nodules after the first FNAc. Cytological diagnoses included 36.6% benign, 12.8% suspicious for malignancy, 1.2% malignant, and 19.7% indeterminate. Among surgically resected thyroid nodules, 78.6% were malignant. US-FNAc demonstrated moderate sensitivity (80%) and high PPV (92.3%) but lower specificity (75%) and NPV (50%) for malignancy in nodules less than 10mm in max diameter. A significant positive correlation (r = 0.24, p < 0.001) was observed between TIRADS classification and TBSRTC.
US-FNAc offers moderate sensitivity and high PPV for diagnosing malignancy in smaller than 10 mm thyroid nodules, but specificity and NPV are lower. A positive correlation exists between TIRADS classification and cytological outcomes.
本回顾性研究评估超声引导下细针穿刺细胞学检查（US-FNAc）对直径小于10mm甲状腺结节的诊断有效性，并探讨甲状腺影像报告和数据系统（TIRADS）分类与US-FNAc报告之间的相关性。
本分析纳入了2022年6月至2023年7月在越南岘港家庭医院内分泌与糖尿病中心就诊的344例患者，共407个直径小于10mm的甲状腺结节。对所有结节均进行了US-FNAc，并根据甲状腺细胞病理学报告贝塞斯达系统（TBSRTC）报告细胞学结果。计算US-FNAc的敏感性、特异性、阳性预测值（PPV）和阴性预测值（NPV）。使用Spearman相关性分析评估细胞学与TIRADS分类之间的相关性。
首次FNAc后，81%的甲状腺结节获得了足够的标本。细胞学诊断包括36.6%为良性、12.8%为恶性可疑、1.2%为恶性以及19.7%为不确定。在手术切除的甲状腺结节中，78.6%为恶性。对于最大直径小于10mm的结节，US-FNAc对恶性肿瘤的敏感性为中等（80%），PPV较高（92.3%），但特异性较低（75%），NPV较低（50%）。TIRADS分类与TBSRTC之间存在显著正相关（r = 0.24，p < 0.001）。
US-FNAc对直径小于10mm的甲状腺结节诊断恶性肿瘤具有中等敏感性和较高的PPV，但特异性和NPV较低。TIRADS分类与细胞学结果之间存在正相关。
