美国与尸体来源的人生长激素相关的克雅氏病，潜伏期长
Cadaveric Human Growth Hormone-Associated Creutzfeldt-Jakob Disease with Long Latency Period, United States.
作者信息
Ribeiro Anatevka S, Wolf Andrew B, Leschek Ellen W, Schonberger Lawrence B, Abrams Joseph Y, Maddox Ryan A, Appleby Brian S, Glisic Katie, Carlson Aaron, Matthews Elizabeth
出版信息
Emerg Infect Dis. 2025 Jun;31(6):1189-1192. doi: 10.3201/eid3106.241519.
We report a case of iatrogenic Creutzfeldt-Jakob disease (iCJD) after a 48.3-year incubation period in a patient treated with cadaveric human growth hormone. iCJD was pathologically confirmed; genetic analysis was negative for pathogenic mutations. Clinicians should consider iCJD in patients with progressive neurologic signs who had received cadaveric human growth hormone treatment.
我们报告了一例医源性克雅氏病（iCJD）病例，该患者在接受尸体来源的人生长激素治疗后，潜伏期长达48.3年。iCJD经病理证实；基因分析未发现致病突变。临床医生应考虑到，接受过尸体来源人生长激素治疗且出现进行性神经体征的患者可能患有iCJD。
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