CRL3 E3 ligase regulates glutamine and cystine metabolisms.

作者信息

Zhou Qiyin, Li Zhijian, Sun Yi

机构信息

Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.

Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou 310029, China.

出版信息

Protein Cell. 2024 Dec 2;15(12):867-871. doi: 10.1093/procel/pwae051.

DOI:10.1093/procel/pwae051

PMID:40440083

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11637989/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be0d/11637989/b3a2b4740042/pwae051_fig1.jpg

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本文引用的文献

[1]

The CRL3 ubiquitin ligase-USP18 axis coordinately regulates cystine uptake and ferroptosis by modulating SLC7A11.

Proc Natl Acad Sci U S A. 2024-7-9

[2]

Protein neddylation and its role in health and diseases.

Signal Transduct Target Ther. 2024-4-5

[3]

Crosstalk between ferroptosis and stress-Implications in cancer therapeutic responses.

Cancer Innov. 2022-6-11

[4]

Tumor microenvironmental nutrients, cellular responses, and cancer.

Cell Chem Biol. 2023-9-21

[5]

Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications.

Cell. 2022-7-7

[6]

Neddylation inhibition induces glutamine uptake and metabolism by targeting CRL3 E3 ligase in cancer cells.

Nat Commun. 2022-5-31

[7]

Cysteine metabolic circuitries: druggable targets in cancer.

Br J Cancer. 2021-3

[8]

Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy.

Protein Cell. 2021-8

[9]

Global site-specific neddylation profiling reveals that NEDDylated cofilin regulates actin dynamics.

Nat Struct Mol Biol. 2020-2-3

[10]

Inhibiting neddylation modification alters mitochondrial morphology and reprograms energy metabolism in cancer cells.

JCI Insight. 2019-2-21

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CRL3 E3 ligase regulates glutamine and cystine metabolisms.

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