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探索流动和移民人口对非洲大规模药物管理覆盖率及效果的影响:一项范围综述方案

Exploring the impact of mobile and migrant populations on mass drug administration coverage and effectiveness in Africa: A scoping review protocol.

作者信息

Sangare Moussa, Coulibaly Yaya Ibrahim, Ravichandran Prithi, Diabate Abdoul Fatao, Duguay Claudia, Vlassoff Carol, Kulkarni Manisha A, Krentel Alison

机构信息

International Center of Excellence in Research in Mali, University of Sciences, Techniques, and Technologies of Bamako, Bamako, Mali.

Interdisciplinary School of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada.

出版信息

PLoS One. 2025 May 29;20(5):e0324949. doi: 10.1371/journal.pone.0324949. eCollection 2025.

Abstract

BACKGROUND

Neglected tropical diseases (NTDs) affect populations in tropical regions, particularly low- and middle-income countries with limited economic and health resources. Mass drug administration (MDA) is a strategy for controlling and eliminating NTDs by treating entire at-risk populations to reduce parasite loads, interrupt transmission, and prevent reinfection. It is cost-effective, and promotes equity by reaching underserved communities. MDA is a critical approach to controlling and eliminating NTDs. Mobile populations in Africa such as nomadic groups and internally displaced persons, may lack access to MDA, which poses challenges to NTD elimination. This study aims to explore the influence of population mobility on the implementation, effectiveness, and sustainability of MDA in Africa.

MATERIALS AND METHODS

This scoping review adheres to the PRISMA extension for scoping reviews and Joanna Briggs Institute (JBI) methodology. PCC (Population, Concept, Context) serves as the foundation for the study. Relevant papers published after 2000 will be identified through a comprehensive search of Medline Ovid, Embase, Web of Science, and gray literature. Studies addressing challenges to MDA in Africa's and related to mobile populations will be included. An Excel spreadsheet modified from the JBI will be used for data extraction and analysis.

CONCLUSION

The results of this review will shed light on how MDA coverage is affected by the phenomenon of mobile and migrant populations and what effective approaches, if any, have been used to address this problem and improve overall population access to MDA.

摘要

背景

被忽视的热带病(NTDs)影响着热带地区的人群,尤其是经济和卫生资源有限的低收入和中等收入国家。群体药物给药(MDA)是一种通过治疗所有高危人群以减少寄生虫负荷、阻断传播并预防再感染来控制和消除NTDs的策略。它具有成本效益,并且通过覆盖服务不足的社区促进公平。MDA是控制和消除NTDs的关键方法。非洲的流动人群,如游牧群体和境内流离失所者,可能无法获得MDA,这给消除NTDs带来了挑战。本研究旨在探讨人口流动对非洲MDA实施、效果和可持续性的影响。

材料与方法

本综述遵循PRISMA扩展的综述方法和乔安娜·布里格斯研究所(JBI)的方法。PCC(人群、概念、背景)作为研究的基础。2000年后发表的相关论文将通过全面检索Medline Ovid、Embase、科学网和灰色文献来确定。将纳入涉及非洲MDA面临的挑战以及与流动人群相关的研究。将使用从JBI修改而来的Excel电子表格进行数据提取和分析。

结论

本综述的结果将阐明流动和移民人群现象如何影响MDA覆盖率,以及是否采用了有效的方法来解决这一问题并改善总体人群获得MDA的机会。

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