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通过计算机辅助诊断改善癌症检测:乳腺热成像中非线性和纹理特征的综合分析

Improving cancer detection through computer-aided diagnosis: A comprehensive analysis of nonlinear and texture features in breast thermograms.

作者信息

Khodadadi Hamed, Nazem Shima

机构信息

Department of Electrical Engineering, Khomeinishahr Branch, Islamic Azad University, Isfahan, Iran.

Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.

出版信息

PLoS One. 2025 May 29;20(5):e0322934. doi: 10.1371/journal.pone.0322934. eCollection 2025.

DOI:10.1371/journal.pone.0322934
PMID:40440412
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12121922/
Abstract

Breast cancer is a significant health issue for women, characterized by its high rates of mortality and sickness. However, its early detection is crucial for improving patient outcomes. Thermography, which measures temperature variations between healthy and cancerous tissues, offers a promising approach for early diagnosis. This study proposes a novel method for analyzing breast thermograms. The method segments suspicious masses, extracts relevant features, and classifies them as benign or malignant. While the chaotic indices, including Lyapunov Exponent (LE), Fractal Dimension (FD), Kolmogorov-Sinai Entropy (KSE), and Correlation Dimension (CD), are employed for nonlinear analysis, the Gray-Level Co-occurrence Matrix (GLCM) method utilized for extracting the texture features. The effectiveness of the proposed approach is enhanced by integrating texture and complexity features. Besides, to optimize feature selection and reduce redundancy, a metaheuristic optimization technique called Non-Dominated Sorting Genetic Algorithm (NSGA III) is applied. The proposed method utilizes various machine learning algorithms, including Support Vector Machine (SVM), K-Nearest Neighbors (KNN), Linear Discriminant Analysis (LDA), Pattern recognition Network (Pat net), and Fitting neural Network (Fit net), for classification. ten-fold cross-validation ensures robust performance evaluation. The achieved accuracy of 98.65%, emphasizes the superior performance of the proposed method in thermograms breast cancer diagnosis.

摘要

乳腺癌是女性面临的一个重大健康问题,其死亡率和患病率都很高。然而,早期检测对于改善患者预后至关重要。热成像技术通过测量健康组织和癌组织之间的温度变化,为早期诊断提供了一种很有前景的方法。本研究提出了一种分析乳房热成像图的新方法。该方法对可疑肿块进行分割,提取相关特征,并将它们分类为良性或恶性。在进行非线性分析时采用了包括李雅普诺夫指数(LE)、分形维数(FD)、柯尔莫哥洛夫-西奈熵(KSE)和关联维数(CD)在内的混沌指标,而用于提取纹理特征的是灰度共生矩阵(GLCM)方法。通过整合纹理和复杂性特征,提高了所提方法的有效性。此外,为了优化特征选择并减少冗余,应用了一种名为非支配排序遗传算法(NSGA III)的元启发式优化技术。所提方法利用了各种机器学习算法,包括支持向量机(SVM)、K近邻算法(KNN)、线性判别分析(LDA)、模式识别网络(Pat net)和拟合神经网络(Fit net)进行分类。十折交叉验证确保了稳健的性能评估。所实现的98.65%的准确率强调了所提方法在乳房热成像图乳腺癌诊断中的卓越性能。

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本文引用的文献

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A Novel CNN pooling layer for breast cancer segmentation and classification from thermograms.一种新的用于从热图像中进行乳腺癌分割和分类的 CNN 池化层。
PLoS One. 2022 Oct 21;17(10):e0276523. doi: 10.1371/journal.pone.0276523. eCollection 2022.
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Detection of Breast Cancer from Five-View Thermal Images Using Convolutional Neural Networks.
使用卷积神经网络从五视图热图像中检测乳腺癌。
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