Sims Catherine, Talabi Mahret Birru
Durham Veterans Affairs Healthcare System, Duke University, 40 Duke Medicine Circle Clinic 1 J, Durham, NC, 27710, USA.
Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, USA.
Curr Rheumatol Rep. 2025 May 29;27(1):26. doi: 10.1007/s11926-025-01191-y.
Patients with rheumatoid arthritis (RA) need tailored guidance when it comes to family planning decisions, including contraception, pregnancy, and breastfeeding. To achieve the best reproductive health outcomes, a coordinated, multidisciplinary approach is essential. This article aims to support healthcare providers in addressing key reproductive health concerns for both male and female patients, such as timing conception, infertility, and the management of RA medications during pregnancy and lactation.
Some women with RA may experience subfertility, however assisted reproductive technology is a safe option. RA disease activity may change for some women during pregnancy, but this is influenced by disease activity going into pregnancy and medication use in pregnancy. Pregnancy complications are more common among women with RA compared to the general population, which may be explained, in part, by disease activity, extra-articular manifestations of RA, and/or use of certain medications. Neonates exposed to biologic medications in utero can receive all recommended vaccinations. Contraception, including emergency contraception, is safe for women with RA. Preliminary data suggests pregnancy termination is safe in women with RA and does not increase the risk for disease flare. RA is a chronic inflammatory disease that can impact both women and men during their reproductive years. Rheumatologists have an essential role in patient's reproductive health and family planning. This article highlights key considerations and offers strategies to assist providers in understanding and supporting their patients' reproductive goals.
类风湿关节炎(RA)患者在计划生育决策方面,包括避孕、怀孕和母乳喂养,需要量身定制的指导。为了实现最佳的生殖健康结果,采用协调一致的多学科方法至关重要。本文旨在帮助医疗服务提供者解决男性和女性患者的关键生殖健康问题,如受孕时机、不孕症以及孕期和哺乳期RA药物的管理。
一些患有RA的女性可能会出现生育力低下的情况,不过辅助生殖技术是一种安全的选择。一些女性在怀孕期间RA疾病活动可能会发生变化,但这受怀孕前的疾病活动和孕期用药的影响。与普通人群相比,患有RA的女性妊娠并发症更为常见,这可能部分归因于疾病活动、RA的关节外表现和/或某些药物的使用。子宫内接触生物制剂的新生儿可以接种所有推荐的疫苗。避孕,包括紧急避孕,对患有RA的女性是安全的。初步数据表明,RA女性终止妊娠是安全的,且不会增加疾病复发的风险。RA是一种慢性炎症性疾病,在育龄期会对男性和女性都产生影响。风湿病学家在患者的生殖健康和计划生育中起着至关重要的作用。本文强调了关键考虑因素,并提供了策略,以帮助医疗服务提供者理解和支持患者的生殖目标。